VITAMIN D AS ONE OF PREDICATORS OF THE STABLE VIRAL RESPONSE TO ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIS HEPATITIS С

  • Larisa Moroz Vinnitsa National Pirogov Memorial Medical University
  • Eltun Engibar Ogli Musaev Vinnitsa National Pirogov Memorial Medical University
  • Olga Androsova Vinnitsa National Pirogov Memorial Medical University
  • Irina Davydyuk Vinnitsa National Pirogov Memorial Medical University
Keywords: chronic hepatitis C, vitamin D, stable viral response

Abstract

Chronic hepatitis C (CHC) it is not exceptionally medical problem but a significant social and economic threat, taking into account the unfavorable consequences of this disease: cirrhosis and hepatocellular carcinoma. And as a result - the high level of disability. In the article are presented the results of examination of 41 patients with chronic hepatitis C, with 1 genotype, who received the antiviral therapy (AVT). All patients underwent determination of the level of 5-hydroxycholeсalсeferol (25-OH vit D3), vitamin D and also the study of IL-28B polymorphism as the one of predicators of response to AVT. It was demonstrated, that in patients with hepatitis was observed the deficit of 25-OH vit D3 and general vitamin D. It was established, that in patients with the normal 25-OH vit D3 level SVR (stable viral response) was observed in 1,4 times more often than in patients with deficit of 25-OH vit D3. That is the level of 25-OH vit Dcan be considered as a predicator of SVR to AVT.

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Author Biographies

Larisa Moroz, Vinnitsa National Pirogov Memorial Medical University

Department of Infectious Diseases with Epidemiology course

Eltun Engibar Ogli Musaev, Vinnitsa National Pirogov Memorial Medical University

Department of Infectious Diseases with Epidemiology course

Olga Androsova, Vinnitsa National Pirogov Memorial Medical University

Department of Infectious Diseases with Epidemiology course

Irina Davydyuk, Vinnitsa National Pirogov Memorial Medical University

Department of Infectious Diseases with Epidemiology course

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Published
2016-07-31
How to Cite
Moroz, L., Musaev, E. E. O., Androsova, O., & Davydyuk, I. (2016). VITAMIN D AS ONE OF PREDICATORS OF THE STABLE VIRAL RESPONSE TO ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIS HEPATITIS С. EUREKA: Health Sciences, (4), 18-22. https://doi.org/10.21303/2504-5679.2016.00117
Section
Medicine and Dentistry