IMMUNE STATUS OF PATIENTS WITH LUNG TUBERCULOSIS AND ALCOHOL CONSUMPTION

Keywords: tuberculosis, alcohol, immune response, innate immunity, AUDIT

Abstract

Tuberculosis is a great medical and social problem. An important risk factor for tuberculosis progress is the systematic use of alcohol. The relationship between alcohol intake and TB has been clear after numerous studies and meta-analyzes. However, there are still open questions about whether alcohol is the direct cause of TB development, which doses of alcohol have the greatest trigger value in progress of TB process, what kind of immunological reactions are significantly associated with alcohol intake and what immune background can determining role of alcohol in progression of TB infection. The features of the immune response in TB patients with different value of alcohol use remain poorly understood.

The aim of the research - to investigate the immune status in patients with firstly diagnosed pulmonary tuberculosis with various levels of alcohol consumption.

Materials and methods. We selected for participating in the study 102 males with tuberculosis and alcohol consumption. Examination of the patients included: clinical methods, chest X-ray, sputum tests, Alcohol Use Disorders Identification Test and immunological blood analysis.

Results. Patients with tuberculosis and alcohol consumption, have increase inflammatory response: higher level of stab neutrophils, CRP, ESR, as well as phagocyte activity, circulating immune complexes levels and medium molecular weight peptides levels. On the other hand we found decreasing of phagocytic number, index of phagocytosis completeness and differentiation clusters CD2+, CD3+, CD4+, CD8+ of T-lymphocytes` sub-populations. The highest changes were observed in the group of alcohol abusers.

Conclusions. Patients with tuberculosis and alcohol intake, even at low levels of its consumption, have a dysregulation of their immune response. On the one hand, there is an increase of non-specific inflammatory reactions, and on the other - a situation, when antigen-presenting cells cannot adequately to process and present the antigen to phagocytes. This prevents the immune system from responding quickly, correctly evaluating and suppressing foreign agents.

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Author Biographies

Maryna Kochuieva, Kharkiv Mediсal Aсademy of Postgraduate Eduсation, V. N. Karazin Kharkiv National University

Department of Phthisiology, Pulmonology and Family Mediсine

Department of General and Clinical Immunology and Allergology

Ivan Hrek, Kharkiv Mediсal Aсademy of Postgraduate Eduсation, V. N. Karazin Kharkiv National University

Department of Phthisiology, Pulmonology and Family Mediсine

Department of General and Clinical Immunology and Allergology

Anton Rogozhyn, Kharkiv Mediсal Aсademy of Postgraduate Eduсation, V. N. Karazin Kharkiv National University

Department of Phthisiology, Pulmonology and Family Mediсine

Department of General and Clinical Immunology and Allergology

Vasyl Kushnir, Kharkiv Mediсal Aсademy of Postgraduate Eduсation, V. N. Karazin Kharkiv National University

Department of Phthisiology, Pulmonology and Family Mediсine

Department of General and Clinical Immunology and Allergology

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Published
2020-03-31
How to Cite
Kochuieva, M., Hrek, I., Klimova, O., Rogozhyn, A., & Kushnir, V. (2020). IMMUNE STATUS OF PATIENTS WITH LUNG TUBERCULOSIS AND ALCOHOL CONSUMPTION. EUREKA: Health Sciences, (2), 8-16. https://doi.org/10.21303/2504-5679.2020.001177
Section
Medicine and Dentistry