Study of structural and mechanical properties of sodium alginate gels

Keywords: sodium alginate, rheology, structural viscosity, shear stress, mechanical stability

Abstract

Rheological parameters are an important characteristic of semisolid dosage forms. Structural and mechanical characteristics have a noticeable effect on the processes of release and absorption of drugs from ointments, as well as on their consumer properties: spreadability, adhesion, the ability to squeeze out of the tubes.

The aim: to study the rheological parameters of aqueous solutions of sodium alginate in various concentrations to create medicinal hydrogel compositions.

Materials and methods: sodium alginate (Shandong Topsea Seaweed Industrial Co., Ltd., China) was used as a gelling agent. The physicochemical properties of the samples were studied according to generally accepted methods of the State Pharmacopoeia of Ukraine. Rheological studies of experimental samples were carried out using a rotational viscometer «Rheolab QC», by Anton Paar (Austria) with coaxial cylinders C-CC27/SS at a temperature 20–25 °С.

Results and discussion: the rheological profiles of sodium alginate gels have a non-Newtonian type of flow, which makes it possible to characterize them as systems with plastic-viscous properties. Gels with a sodium alginate concentration of 1.5–2 % have the best indicators of yield stress, hysteresis loop area, mechanical stability and dynamic flow coefficients. This indicates a low degree of destruction of the structural grid in the process of mechanical action and the presence of thixotropic bonds.

Conclusions: sodium alginate gel base at 0.5 % and 1 % concentration is less stable under stress compared to sodium alginate bases at 1.5 % and 2 % concentration. The gel base of sodium alginate at a concentration of 2 % has the optimal mechanical stability value.

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Author Biographies

Ievgenii Gladukh, National University of Pharmacy

Department of Pharmaceutical Technology of Drugs

Maiia Podorozhna, National University of Pharmacy

Department of Pharmaceutical Technology of Drugs

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Published
2021-03-31
How to Cite
Gladukh, I., & Podorozhna, M. (2021). Study of structural and mechanical properties of sodium alginate gels. EUREKA: Health Sciences, (2), 82-89. https://doi.org/10.21303/2504-5679.2021.001732
Section
Pharmacology, Toxicology and Pharmaceutical Science