• Elchin Mammad oglu Huseynov Azerbaijan Medical University
Keywords: acute brucellosis, interleukin-4, interleukin-6, toll-like receptors, immunoglobulin


It is well known, that the injury of organs and systems and also immunological rates considerably determine clinical course and the result of brucellosis. In the article are presented the results of examination of 120 patients with acute brucellosis. The control group included 30 practically healthy persons. Groups were representative by the age and sex. The diagnosis of brucellosis was set on the base of complaints, anamnesis, epidemiological and clinical data and the results of serological examination of the blood. All patients also underwent the fixation of interleukin -6, іinterleukin-4 and TLR-2 in the blood serum. The detailed epidemiological, clinical and immunological characteristic of patients with brucellosis was presented. Among examined persons prevailed men, persons of young able-bodied persons and rural dwellers. It was revealed, that the dominating way of transmission was the contact one. The highest level of infection was fixed among the workers of farm enterprises and veterinarians. The season features were also revealed, the highest level of morbidity was in summer-autumn period. The main clinical features were: fever, arthralgia, risen disposition to perspire, hepatosplenomegaly. It was revealed, that the level of pro-inflammatory interleukins considerably prevailed over the level of anti-inflammatory ones. Despite the high sensitivity of PCR diagnostics, the positive results in our research were received only in one third of patients.


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Author Biography

Elchin Mammad oglu Huseynov, Azerbaijan Medical University

Department of Infectious Diseases


Kenzhebekova, G. B. (2012). Brucellosis and its prevention. Hygiene, Epidemiology and immunobiology, 4, 52–55.

Ustun, N. M. (2010). Epidemiological characteristics of brucellosis among the population of Azerbaijan. ATJ, 3, 133–137.

Pappas, G., Akritidis, N., Bosilkovski, M., Tsianos, E. (2005). Brucellosis. New England Journal of Medicine, 352 (22), 2325–2336. doi: 10.1056/nejmra050570

Atahodzhaeva, D. R. (2013). Clinical and immunological characteristics of acute brucellosis in children. Zaporozhye Medical Journal, 6 (81), 6–9.

Tsirelson, L. E., Zheludkov, M. M. (2011). Brucellosis in Russia: Occupational diseases and employment outlook. Epidemiology and Infectious Diseases, 5, 43–47.

Ismailova, R. I. (2004). Epizootologichesky and epidemiological situation of brucellosis in the new conditions of animal breeding in Azerbaijan. Problem of dangerous infectious, 87, 22–24.

Ryaplova, I. V. (2008). Modern features of epidemic process of brucellosis. Perm, 28.

Nafeev, A. A., Burtaeva, N. T., Nikulkina, N. P., Bezique, V. V. (2012). Epidemic manifestations of brucellosis in the prosperous area. Epidemiology and Infectious Diseases, 4, 40–43.

Pavlova, O. M. (2004). Clinical and immunological features of brucellosis. Rostov on Don, 32.

Pappas, G., Papadimitriou, P., Akritidis, N., Christou, L., Tsianos, E. V. (2006). The new global map of human brucellosis. The Lancet Infectious Diseases, 6 (2), 91–99. doi: 10.1016/s1473-3099(06)70382-6

Troy, S. B., Rickman, L. S., Davis, C. E. (2005). Brucellosis in San Diego. Medicine, 84 (3), 174–187. doi: 10.1097/

Bairakov, A. L., Voropaeva, E. A., Afanasyev, S. S., Egorova, E. A. et. al. (2008). The role and biological significance of Toll-like receptors in the body's anti-infective resistance. Vestn. RAMS, 1, 45–54.

Zheludkov, M. M., White, J. F., Kulakov, J. K. (2004). Using recombinant proteins in ELISA test system for the diagnosis of brucellosis. Development of international cooperation in the area of infectious diseases. Novosibirsk, 146.

Zheludkov, M. M., Kulakov, J. K., Alekseeva, N. V., Tolmacheva, T. A. (2005). PCR in the diagnosis of brucellosis. Clin. Lab. Diagnostics, 9, 58–59.

Kulakov, J. K., Zheludkov, M. M., Tolmacheva, T. A., Tsirelson, L. E. (2010). PCR method in the laboratory diagnosis of brucellosis. Epidemiology and vaccine prophylaxis, 2 (51), 29–33.

Kadyrov, S. H., Zhankin, A. A., Kurmanova, G. M. (2009). Comparative characteristics of patients with acute brucellosis in conditions of chronic intoxication with salts of lead and cadmium. Bulletin of the Kazakh National Medical University. Scientific and practical journal "Infectious diseases, microbiology, epidemiology", 1, 36–39.

Godfroid, J., Scholz, H. C., Barbier, T., Nicolas, C., Wattiau, P., Fretin, D. et. al. (2011). Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century. Preventive Veterinary Medicine, 102 (2), 118–131. doi: 10.1016/j.prevetmed.2011.04.007

Safonov, A. D., Nurpeysova, A. N., Berezkina, G. V. (2008). Comparative effectiveness of laboratory methods for diagnosis of brucellosis. Infectious diseases: current diagnosis and treatment of problems: the materials of the Russian scientific-practical conference. Stankt Petersburg, 214–215.

Duysenova, A. K. Zoonotic infections: yesterday, today and tomorrow. Available at:

Popov, P. N. (2009). The classification of modern brucellosis. Epidemiology and Infectious Diseases, 6, 54–56.

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How to Cite
Huseynov, E. M. oglu. (2016). THE FEATURES OF ACUTE BRUCELLOSIS IN AZERBAIJAN REPUBLIC. EUREKA: Health Sciences, (6), 10-15.
Medicine and Dentistry