Determination of the relationship of visphatin and homocysteine levels with indicators of glucose metabolism and lipid metabolism in peri- and postmenopause women with type 2 diabetes mellitus and osteoarthritis

Keywords: type 2 diabetes mellitus, osteoarthritis, visfatin, homocysteine, women, perimenopause, postmenopause, metabolism


Type 2 diabetes mellitus (T2DM), among other modern diseases, certainly occupies a leading position today. Moreover, the comorbid combination of T2DM and osteoarthritis (OA) is a common example of the development of complications, disability and mortality these days. As you know, T2DM develops against the background of obesity and overweight. A significant group of patients prone to these pathologies are peri- and postmenopausal women. Estrogen deficiency during this period worsens the course of these interdependent conditions. Therefore, searching for ways of early diagnosis of OA in women with T2DM is an urgent task of internal medicine.

Purpose. To determine the interdependencies of indicators of glucose metabolism and lipid metabolism with levels of visfatin (VF) and homocysteine (HC) in women with T2DM and OA in peri- and postmenopause.

Methods. For the study, 120 thematic women in peri- and postmenopause were selected and were divided into three groups: 1st (n=20) - women with a mono-course of T2DM; 2nd (n=20) – with a mono-course of OA; 3rd (n=64) – with the comorbid course of T2DM and OA. The control group (CG) consisted of 16 relatively healthy women of the appropriate age. Diagnoses of T2DM and OA were established in accordance with the current Orders of the Ministry of Health of Ukraine. Laboratory diagnostic methods were performed according to standard methods.

The results. According to the obtained results, the presence of interdependencies of all indicators of lipid metabolism and glucose-insulin metabolism was reliably determined, which indicated direct correlations (mostly of moderate strength) with the levels of HC and VF in the blood of the examinees, most pronounced in the comorbid combination of T2DM and OA in peri- and postmenopause.

Conclusions. In work, an analysis of the correlations of indicators of glucose metabolism and lipid metabolism with disturbances in the metabolism of VF and HC in women with T2DM and OA in pre- and postmenopause was carried out, and their interdependent relationships were determined. The highest levels of VF and HC were recorded in the group of women with comorbid pathology of T2DM and OA.


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Author Biographies

Larysa Zhuravlyova, Kharkiv National Medical University

Department of Internal Medicine No. 3 and Endocrinology

Valentyna Cherpita, Kharkiv National Medical University

Department of Internal Medicine No. 3 and Endocrinology


Dzyuba, O. M., Pazynych, L. M., Sitenko, O. R., Kryvenko, Ye. M. (2017). The actual questions of global burden of diseases in Ukraine. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, 2, 8–13. doi:

WHO. The top 10 causes of death (2020). Available at: Last assessed: 11.11.2020

Zhou, B., Lu, Y., Hajifathalian, K., Bentham, J., Di Cesare, M., Danaei, G. et al. (2016). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants. The Lancet, 387 (10027), 1513–1530. doi:

Lin, X., Xu, Y., Pan, X., Xu, J., Ding, Y., Sun, X. et al. (2020). Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Scientific Reports, 10 (1). doi:

Ogurtsova, K., da Rocha Fernandes, J. D., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H. et al. (2017). IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Research and Clinical Practice, 128, 40–50. doi:

Simon, C., Narayanan, N., Binu, J., Rajmohan, P. (2017). Prevalence and Risk Factors of Type 2 Diabetes Mellitus among Adults in a Rural Area of Thrissur, Kerala (Type 2 Diabetes among Adults in Rural Thrissur, Kerala). Journal of Medical Science and Clinical Research, 5. (9), 28303–28310. doi:

IDF. International Diabetes Federation. IDF Diabetes Atlas (2015). Belgium.

IDF Western Pacific. International diabetes federation (2020). Available at:

Onyango, E. M., Onyango, B. M. (2018). The Rise of Noncommunicable Diseases in Kenya: An Examination of the Time Trends and Contribution of the Changes in Diet and Physical Inactivity. Journal of Epidemiology and Global Health, 8 (1-2). doi:

Seiglie, J. A., Marcus, M.-E., Ebert, C., Prodromidis, N., Geldsetzer, P., Theilmann, M. et al. (2020). Diabetes Prevalence and Its Relationship With Education, Wealth, and BMI in 29 Low- and Middle-Income Countries. Diabetes Care, 43 (4), 767–775. doi:

Cowie, C. C., Casagrande, S. S., Geiss, L. S. (2018). Prevalence and Incidence of Type 2 Diabetes and Prediabetes. Diabetes in America. National Institute of Diabetes and Digestive and Kidney Diseases (US), Bethesda (MD).

Global Burden of Disease database (2017). Institute for health metrics and evaluation. Seattle, Washington.

Alva, P., Bhandary, A., Bhandary, P., Hegde, P., Souza, N. D., Kumari, S. (2021). Correlation of Body Mass Index with Lipid Profile and Estradiol in Postmenopausal Women with Type 2 Diabetes Mellitus. International Journal of Current Research and Review, 13 (1), 107–110. doi:

Porta, S., Otero-Losada, M., Kölliker Frers, R. A., Cosentino, V., Kerzberg, E., Capani, F. (2021). Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis. Frontiers in Immunology, 11. doi:

Zheng, Y., Ley, S. H., Hu, F. B. (2017). Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature Reviews Endocrinology, 14 (2), 88–98. doi:

Lascar, N., Brown, J., Pattison, H., Barnett, A. H., Bailey, C. J., Bellary, S. (2018). Type 2 diabetes in adolescents and young adults. The Lancet Diabetes & Endocrinology, 6 (1), 69–80. doi:

Asiimwe, D., Mauti, G. O., Kiconco, R. (2020). Prevalence and Risk Factors Associated with Type 2 Diabetes in Elderly Patients Aged 45-80 Years at Kanungu District. Journal of Diabetes Research, 2020, 1–5. doi:

Mobasseri, M., Shirmohammadi, M., Amiri, T., Vahed, N., Hosseini Fard, H., Ghojazadeh, M. (2020). Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis. Health Promotion Perspectives, 10 (2), 98–115. doi:

Hevko, U. P., Dikova, I. G., Maksiv, Kh. Ya., Dzyha, S. V., Bakalets, O. V., Behosh, N. B. (2021). Type 2 diabetes mellitus and its comorbidity. Bulletin of Medical and Biological Research, 4, 132–136. doi:

Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020: Estimates of Diabetes and Its Burden in the United States. Centers for Disease Control and Prevention, U.S (2020). Dept of Health and Human Services. Available at: Last accessed: 22.12.2020

Song, P., Hwang, J. S., Park, H. C., Kim, K. K., Son, H.-J., Kim, Y.-J., Lee, K. M. (2021). Therapeutic Applications of Type 2 Diabetes Mellitus Drug Metformin in Patients with Osteoarthritis. Pharmaceuticals, 14 (2), 152. doi:

Konnur, R. G. (2021). Osteoarthritis and Menopause. International Journal of Orthopedic Nursing, 7 (1), 1–8.

Mahajan, A., Patni, R. (2018). Menopause and Osteoarthritis: Any Association ? Journal of Mid-Life Health, 9 (4), 171–172. doi:

Wu, J. H. et al. (2021). Prevalence and risk factors of osteoarthritis in patients with type 2 diabetes in Beijing, China from 2015 to 2017. Journal of Peking University. Health Sciences, 53 (3), 518–522. doi: 10.19723/j.issn.1671-167x.2021.03.013

Gürsoy, G., Akçayöz, S., Acar, Y., Demirba, B. (2011). Visfatin in hyperlipidemic female patients. International Journal of Medical Advances and Discovery, 2 (5), 1–6.

Koebnick, C., Black, M. H., Wu, J., Shu, Y.-H., MacKay, A. W., Watanabe, R. M. et al. (2018). A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile. British Journal of Nutrition, 120 (11), 1230–1239. doi:

Bitto, A., Arcoraci, V., Alibrandi, A., D’Anna, R., Corrado, F., Atteritano, M., Minutoli, L., Altavilla, D., Squadrito, F. (2016). Visfatin correlates with hot flashes in postmenopausal women with metabolic syndrome: effects of genistein. Endocrine, 55 (3), 899–906. doi:

Hug, C., Lodish, H. F. (2005). Visfatin: A New Adipokine. Science, 307 (5708), 366–367. doi:

Kim, J.-H., Kim, S.-H., Im, J.-A., Lee, D.-C. (2010). The relationship between visfatin and metabolic syndrome in postmenopausal women. Maturitas, 67 (1), 67–71. doi:

Chhezom, K., Arslan, M. I., Hoque, Md. M., Biswas, S. K. (2017). Biomarkers of cardiovascular and metabolic diseases in otherwise healthy overweight subjects in Bangladesh. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 11, S381–S384. doi:

Farkhondeh, T., Llorens, S., Pourbagher-Shahri, A. M., Ashrafizadeh, M., Talebi, M., Shakibaei, M., Samarghandian, S. (2020). An Overview of the Role of Adipokines in Cardiometabolic Diseases. Molecules, 25 (21), 5218. doi:

Bawah, A. T., Seini, M. M., Abaka-Yawason, A., Alidu, H., Nanga, S. (2019). Leptin, resistin and visfatin as useful predictors of gestational diabetes mellitus. Lipids in Health and Disease, 18 (1). doi:

Ezzati-Mobaser, S., Malekpour-Dehkordi, Z., Nourbakhsh, M., Tavakoli-Yaraki, M., Ahmadpour, F., Golpour, P., Nourbakhsh, M. (2020). The up-regulation of markers of adipose tissue fibrosis by visfatin in pre-adipocytes as well as obese children and adolescents. Cytokine, 134, 155193. doi:

Wnuk, A., Stangret, A., Wątroba, M., Płatek, A. E., Skoda, M., Cendrowski, K. et al. (2020). Can adipokine visfatin be a novel marker of pregnancy‐related disorders in women with obesity? Obesity Reviews, 21 (7). doi:

Parker, R., Kim, S.-J., Gao, B. (2017). Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations. Nature Reviews Gastroenterology & Hepatology, 15 (1), 50–59. doi:

Guoli, C., Kuichen, Z., Liqiu, L., Sheng, L. I. (2016). Relevance of serum visfatin, lipoprotein-a and homocysteine in diabetic nephropathy. Chinese Journal of Biochemical Pharmaceutics, 36 (6), 182–184.

Filippatos, T., Randeva, H., Derdemezis, C., Elisaf, M., Mikhailidis, D. (2010). Visfatin/PBEF and Atherosclerosis-Related Diseases. Current Vascular Pharmacology, 8 (1), 12–28. doi:

Uslu, S., Kebapçi, N., Kara, M., Bal, C. (2012). Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 4 (1), 113–120. doi:

Franco-Trepat, E., Guillán-Fresco, M., Alonso-Pérez, A., Jorge-Mora, A., Francisco, V., Gualillo, O., Gómez, R. (2019). Visfatin Connection: Present and Future in Osteoarthritis and Osteoporosis. Journal of Clinical Medicine, 8 (8), 1178. doi:

Tsai, C.-H., Liu, S.-C., Chung, W.-H., Wang, S.-W., Wu, M.-H., Tang, C.-H. (2020). Visfatin Increases VEGF-Dependent Angiogenesis of Endothelial Progenitor Cells during Osteoarthritis Progression. Cells, 9 (5), 1315. doi:

Moretti, R., Caruso, P. (2019). The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice. International Journal of Molecular Sciences, 20 (1), 231. doi:

Chrysant, S. G., Chrysant, G. S. (2018). The current status of homocysteine as a risk factor for cardiovascular disease: a mini review. Expert Review of Cardiovascular Therapy, 16 (8), 559–565. doi:

Djuric, D., Jakovljevic, V., Zivkovic, V., Srejovic, I. (2018). Homocysteine and homocysteine-related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems. Canadian Journal of Physiology and Pharmacology, 96 (10), 991–1003. doi:

Zaric, B. L., Obradovic, M., Bajic, V., Haidara, M. A., Jovanovic, M., Isenovic, E. R. (2019). Homocysteine and Hyperhomocysteinaemia. Current Medicinal Chemistry, 26 (16), 2948–2961. doi:

Smith, A. D., Refsum, H. (2021). Homocysteine – from disease biomarker to disease prevention. Journal of Internal Medicine, 290 (4), 826–854. doi:

Azzini, E., Ruggeri, S., Polito, A. (2020). Homocysteine: Its Possible Emerging Role in At-Risk Population Groups. International Journal of Molecular Sciences, 21 (4), 1421. doi:

Saito, M., Marumo, K. (2018). The Effects of Homocysteine on the Skeleton. Current Osteoporosis Reports, 16 (5), 554–560. doi:

Hindy, G., Åkesson, K. E., Melander, O., Aragam, K. G., Haas, M. E., Nilsson, P. M. et al. (2019). Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes: A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank. Arthritis & Rheumatology, 71 (6), 925–934. doi:

Tsiklauri, L., Werner, J., Frommer, K., Engel, R., Rehart, S., Wenisch, S. et al. (2018). Visfatin in bone metabolism of osteoporosis and osteoarthritis patients. Poster Presentations. doi:

Çıkım, G., Veranyurt, Ü. (2021). Evaluation of homocysteine and vitamin d levels in osteoarthritis patients. NWSA Academic Journals, 16 (2), 68–73. doi:

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How to Cite
Zhuravlyova, L., & Cherpita, V. (2023). Determination of the relationship of visphatin and homocysteine levels with indicators of glucose metabolism and lipid metabolism in peri- and postmenopause women with type 2 diabetes mellitus and osteoarthritis. EUREKA: Health Sciences, (1), 34-42.
Medicine and Dentistry

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