36 MONTHS SURVIVABILITY AND ITS PREDICTORS IN PATIENTS WITH CHRONIC HEART FAILURE AND DECREASED FRACTION OF LEFT VENTRICULAR EJECTION DEPENDING ON SEX
Abstract
Aim of the work: to compare survivability parameters during 36 months and their predictors among men and women with chronic heart failure and decreased fraction of left ventricular ejection.
Materials and methods: the research included 356 patients with CHF (NYHA ІІ –ІV) with decreased LVEF<40 %, 18–75 years old. Using Kaplan-Meier method, there was analyzed the survivability in men and women during 36 months, then there were analyzed independent factors that influenced survivability terms depending on sex using the multiple logistic regression.
Results. Our analysis of the survivability of patients with CHF with decreased LVEF demonstrated that the cumulative survival after 3 years of observation was 49 and 51 % for men and women, respectively. The curves of 36 months survivability didn’t reliably differ. At the analysis of factors, associated with the bad prognosis, there were observed differences between groups of men and women with CHF. Thus, in men the predictors of 36 month survival were: the thickness of the right ventricle wall, size of the right atrium, end-diastolic volume and end-systolic volume of LV, indices of EDV and ESV of LV, urinary acid level, value of LVEF. In women the predictors of survivability during 3 years were the following parameters: BMI, DM type 2 in an anamnesis, end-diastolic size of LV, end-systolic size of LV, blood glucose level, LVEF.
Conclusion. The survivability of men and women with CHF with decreased LVEF during 36 months didn’t reliably differ and was 49 and 51 % respectively. But predictors of the lethal outcome in men and women essentially differed during 36 months, and their number is essentially higher in men.
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References
Voronkov, L. G. (2012). A patient with CHF in Ukraine: an analysis of the data of the population of patients surveyed in the framework of the first national study UNIVERS. Sertseva nedostatnist [Heart Failure], 2, 6–13.
Drozdova, I. V., Vasylieva, L. O., Babets, A. A. (2016). Tserebro-vaskuliarni khvoroby v Ukraini: do pytannia analizu ta prohnozuvannia. East European Scientific Journal, 6 (10), 8–12.
Kovalenko, V. M., Dorogoy, A. P. (2016). Sertsevo-sudinn hvorobi: medichno-sotsialne znachennya ta strategiya rozvitku kardiologiyi v Ukrayini. Ukrayinskiy kardiologichniy zhurnal [Ukrainian Cardiology Journal], 3, 5–14.
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M. et. al. (2015). Heart Disease and Stroke Statistics–2015 Update. Circulation, 131 (4), 29–322. doi:10.1161/cir.0000000000000152
Gastelurrutia, P., Gastelurrutia, M. A., Faus, M. J., Bayes-Genis, A. (2012). Common health problems management uncertainties in heart failure: a qualitative study. Farmacia hospitalaria, 36 (6), 498–505.
Bakhshaliev, A. B., Dadashova, G. M., Bakhshalieva, G. I. (2015). Gender-related features of risk factors for, and age- and gender-related differences in the severity and genesis of chronic heart failure. Terapevticheskii Arkhiv, 87 (4), 13–18. doi: 10.17116/terarkh20158713-18
Dadashova, G. M. (2015). Gender specific features of chronic heart failure. Klinicheskaya meditsina [Clinical Medicine], 1, 71–75.
Khalid, A., Bhatti, S. K., Al-Amoodi, M. (2012). Clinical factors associated with left ventricular ejection fraction disparity in patients with left ventricular dysfunction undergoing multimodality imaging. Missouri Medicine, 109 (6), 489–492
Liu, M., Lee, A. P., Sun, J. P. et. al. (2012). Risk stratification for 1 year mortality in patients with heart failure and normal ejection fraction. European Heart Journal, 33 (1), 518—519.
O’Connor, C. M., Abraham, W. T., Albert, N. M., Clare, R., Gattis Stough, W., Gheorghiade, M. et. al. (2008). Predictors of mortality after discharge in patients hospitalized with heart failure: An analysis from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). American Heart Journal, 156 (4), 662–673. doi: 10.1016/j.ahj.2008.04.030
Recommendations on the diagnosis and treatment of chronic heart failure of the Association of Cardiologists of Ukraine and the Ukrainian Association of Cardiac Insufficiency (2012). Sertseva nedostatnist [Heart Failure], 3, 60–96.
Kovalenko, V. N. (Ed.) (2008). The Cardiology Guide. National Scientific Center «M. D. Strazhesko of NAMS of Ukraine». Kyiv: MORION, 1424.
Petri, A., Sebin, K. (2003). Medical Statistics at a Glance. Kyiv: GEOTAR-MED, 143.
Rebrova, O. Yu. (2002). Statistichniy analiz medichnih danih. Zastosuvannya paketu prikladnih program STATISTICA. Мoscow: Medif Sfera [Medif Sphere], 312.
Buring, J. E. (2000). Women in Clinical Trials — A Portfolio for Success. New England Journal of Medicine, 343 (7), 505–506. doi: 10.1056/nejm200008173430711
Aleksander, K., Klabnik, K., Murin, Ya. (2013). Chronic Heart Failure in women. Liki Ukrayini [Medicines of Ukraine], 7, 80–83.
Klapholz, V. (2004). Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: results of the New York. Heart Failure Registry, 43, 1432–1438.
Tsuchihashi-Makaya, M., Hamaguchi, S., Kinugawa, S., Yokota, T., Goto, D., Yokoshiki, H. et. al. (2009). Characteristics and Outcomes of Hospitalized Patients With Heart Failure and Reduced vs Preserved Ejection Fraction. Circulation Journal, 73 (10), 1893–1900. doi: 10.1253/circj.cj-09-0254
Regitz-Zagrosek, V., Oertelt-Prigione, S., Seeland, U., Hetzer, R. (2010). Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure. Circulation Journal, 74 (7), 1265–1273. doi: 10.1253/circj.cj-10-0196
Figueredo, V. M., Camacho, S. A. (1994). Basic mechanisms of myocardial dysfunction. Current Opinion in Cardiology, 9 (3), 272–279. doi: 10.1097/00001573-199405000-00003
Copyright (c) 2017 Leonid Voronkov, Elena Filatova, Alina Lyashenko, Natalya Tkach, Pavel Babych
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