SUBSTANTIATION FOR THE TECHNOLOGY OF OBTAINING ANTIMICROBIAL SPRAY ON THE BASIS OF SILVER AND COPPER CITRATES
Formation and development of the veterinary pharmacy and veterinary drugs market in Ukraine is an urgent issue. In order to prevent infection of the mammary gland in cows after milking, the nipples are treated with a suitable disinfectant for complete immersion or spraying. However, the agents for the prevention of mastitis, presented in the Ukrainian market, are expensive and there is a need to develop domestic veterinary preparations of different forms of release.
This work is a continuation of research on the development of the composition and technology of a means for antiseptic treatment of nipples and udders of cattle, in the form of a spray, in order to prevent microbial contamination and prevent mastitis.
To obtain a stable veterinary drug based on citrate of silver and copper, the dissolution regimes of the substances were investigated, the order of introduction of the active ingredients and auxiliary substances into the solution, the duration and the rate of stirring during dissolution. It is established that the most optimal are the following technological modes of spray preparation: dissolution temperature 20-220С, mixing time from 10 to 15 minutes, with stirring intensity from 150-200 sec-1. The selected technological regime ensures the stability of the veterinary drug "Argocide-copper" during storage for 12 months. The technology of obtaining a spray in the conditions of industrial production of veterinary preparations of LLC "Brovafarm" (Brovary, Ukraine) is developed. Critical stages and critical control points in the production process of a veterinary preparation of antiseptic action are determined.
Polova, Zh. M. (2014). Analiz rynku veterynarnykh likarskykh form dlia zastosuvannia v akusherstvi ta hinekolohii. Farmatsevtychnyi chasopys, 4 (32), 129–134.
De Vliegher, S., Fox, L. K., Piepers, S., McDougall, S., Barkema, H. W. (2012). Invited review: Mastitis in dairy heifers: Nature of the disease, potential impact, prevention, and control. Journal of Dairy Science, 95 (3), 1025–1040. doi: 10.3168/jds.2010-4074
Ruegg, P. L. (2009). Management of mastitis on organic and conventional dairy farms1. Journal of Animal Science, 87, 43–55. doi: 10.2527/jas.2008-1217
Sinha, M. K., Thombare, N. N., Mondal, B. (2014). Subclinical Mastitis in Dairy Animals: Incidence, Economics, and Predisposing Factors. The Scientific World Journal, 2014, 1–4. doi: 10.1155/2014/523984
Ranjan, R., Gupta, M. K., Singh, S., Kumar, S. (2010). Current trend of drug sensitivity in bovine mastitis. Veterinary World, 3 (1), 17–20.
Yarnykh, T. H., Orlovetska, N. F., Khokhlenkova, N. V., Dukhnytskyi, V. B., Chushenko, V. M.; Yarnykh, T. H. (Ed.) (2010). Praktykum z tekhnolohii veterynarnykh preparativ. Kharkiv: NFaU, 179.
Nemchenko, A., Polova, Z., Nazarkina, V., Simonyan, L. (2017). Marketing researches of the veteri nary drugs market used in mastitis treatment of cattle. Management, Economics and Quality Assurance in Pharmacy, 2 (50), 93–97. doi: 10.24959/uekj.17.17
Garvey, M., Curran, D., Savage, M. (2016). Efficacy testing of teat dip solutions used as disinfectants for the dairy industry: Antimicrobial properties. International Journal of Dairy Technology, 70 (2), 179–187. doi: 10.1111/1471-0307.12344
Mason, S. E., Mullen, K. A. E., Anderson, K. L., Washburn, S. P., Yeatts, J. L., Baynes, R. E. (2017). Pharmacokinetic analysis of thymol, carvacrol and diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle./ Food Additives & Contaminants: Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment, 70 (2), 179–187. doi: 10.1080/19440049.2017.1285056
DeLaval. Available at: https://www.delaval.com/en-us/
Martins, C. M. M. R., Pinheiro, E. S. C., Gentilini, M., Benavides, M. L., Santos, M. V. (2017). Efficacy of a high free iodine barrier teat disinfectant for the prevention of naturally occurring new intramammary infections and clinical mastitis in dairy cows. Journal of Dairy Science, 100 (5), 3930–3939. doi: 10.3168/jds.2016-11193
French, E. A., Mukai, M., Zurakowski, M., Rauch, B., Gioia, G., Hillebrandt, J. R. et. al. (2016). Iodide Residues in Milk Vary between Iodine-Based Teat Disinfectants. Journal of Food Science, 81 (7), 1864–1870. doi: 10.1111/1750-3841.13358
Polova, Zh. M., Nazarkina, V. M. (2017). The analysis of economic availability of veterinary preparations in the segment of anti-mastitis medicines. Social Pharmacy in Health Care, 3 (3), 35–41. doi: 10.24959/sphhcj.17.86
Polova, Zh. M. (2016). Doslidzhennia antymikrobnoi aktyvnosti tsytrativ sribla ta midi z metoiu rozrobky farmatsevtychnykh preparativ. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 1 (20), 71–74
Polova, Zh. M. (2016). Mikrobiolohichni doslidzhennia antyseptychnoho zasobu. Zbirnyk naukovykh prats spivrobitnykiv NMAPO imeni P.L.Shupyka, 25 (1), 563–568.
Bezuglyi, P. O., Ukrayinecz, I. V., Taran, S. G. et. al.; Bezuglyi, P. O. (Ed.) (2002). Pharmaceutical chemistry. Kharkiv: National University of Pharmacy, 448.
State Pharmacopoeia of Ukraine. Vol. 1 (2015). Kharkiv: State Enterprise "Ukrainian Research Center expert pharmacopoeia drug quality", 1128.
Liapunov, M. et. al. (2012). Likarski zasoby. Farmatsevtychna rozrobka (ICH Q8): Nastanova ST N MOZU 42-3.0:2011. Kyiv: MOZU Ukrainy, 35.
Commission Directive 91/412/EEC of 23 July 1991 laying down the principles and guidelines of good manufacturing practice for veterinary medicinal products (1991). J. of the Eur. Com. L, 228, 70–73.
Commission Directive 2009/9/EC of 10 February 2009 amending Directive 2001/82/EC of the European Parliament and of the Council on the Community code relating to medicinal products for veterinary use (2009). Official Journal, 44, 10–61.
Metodychni rekomendatsii shchodo osnovnykh pravyl nalezhnoi praktyky vyrobnytstva ta kontroliu yakosti veterynarnykh preparativ [Methodological recommendations on the basic rules of good manufacturing practice and quality control of veterinary drugs] (2014). Available at: http://search.ligazakon.ua/l_doc2.nsf/link1/FN001635.html
Copyright (c) 2018 Zhanna Polova, Lyudmyla Almakayeva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.