Low-molecular components of colostrum as a regulator of the organism redox-system and biological antidote
Abstract
The protein composition in the diapason of molecular masses from 4800 to 9500 Dа has been studied in colostrum, taken from different cows, and manifested the expressed biological activity. For this aim, an influence of low-molecular components of colostrum on some physiological parameters (change of body mass and temperature) at intoxication of animals (Wistar rats) by blue stone has been studied. An influence of colostrum low-molecular components on parameters of the organism redox-system (content of hyperperoxides of lipids and activity of glutathione peroxidase) in the blood serum of animals has been studied. For determining integral characteristics of colostrum components, electric conductivity of skim colostrum and one of colostrum with low-molecular proteins (less than 10 000 Dа), taken from different cows, were used. The aim of this work is to study interconnections of an influence of colostrum low-molecular proteins on models of organism intoxication by cooper ions.
It is demonstrated, that the colostrum composition includes 25–35 different proteins with a molecular mass from 4800 to 9500 Dа. The number and ratio between protein fractions depend on individual physiological-biochemical characteristics of producers. It has been revealed, that there is no direct dependence between the protein content in a measuring cell (2 mg/ml, 4 mg/ml and 10 mg/ml) with skim colostrum and electric conductivity change, and this dependence is different for skim colostrum, taken from different cows. Individual differences are manifested both at electric conductivity change and by the content of colostrum low-molecular proteins in a measuring cell. It is demonstrated, that colostrum low-molecular components can eliminate the toxic effect of blue stone on the organism, which mechanisms are connected with a balance shift in the system “prooxidants↔antioxidants” towards antioxidants. The electric conductivity of colostrum components may be used as an express-method for evaluating biologically active substances of colostrum
Downloads
References
Koletzko, B., Chourdakis, M., Grote, V., Hellmuth, C., Prell, C., Rzehak, P. et. al. (2014). Regulation of Early Human Growth: Impact on Long-Term Health. Annals of Nutrition and Metabolism, 65 (2-3), 101–109. doi: https://doi.org/10.1159/000365873
Brands, B., Demmelmair, H., Koletzko, B. (2014). How growth due to infant nutrition influences obesity and later disease risk. Acta Paediatrica, 103 (6), 578–585. doi: https://doi.org/10.1111/apa.12593
Bozhkov, A. I., Nikitchenko, Yu. V., Al-Bahadly Ali, M. M. (2016). Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan. Journal of Gerontology & Geriatric Research, 5 (3). doi: https://doi.org/10.4172/2167-7182.1000309
Baintner, K. (2007). Transmission of antibodies from mother to young: Evolutionary strategies in a proteolytic environment. Veterinary Immunology and Immunopathology, 117 (3-4), 153–161. doi: https://doi.org/10.1016/j.vetimm.2007.03.001
Callahan, G. N., Yates, R. M. (2014). Basic veterinary immunology. University Press of Colorado, 337.
Li, M., Li, Q., Kang, S., Cao, X., Zheng, Y., Wu, J. et. al. (2020). Characterization and comparison of lipids in bovine colostrum and mature milk based on UHPLC-QTOF-MS lipidomics. Food Research International, 136, 109490. doi: https://doi.org/10.1016/j.foodres.2020.109490
McGrath, B. A., Fox, P. F., McSweeney, P. L. H., Kelly, A. L. (2016). Composition and properties of bovine colostrum: a review. Dairy Science & Technology, 96 (2), 133–158. doi: https://doi.org/10.1007/s13594-015-0258-x
Borad, S. G., Singh, A. K. (2018). Colostrum immunoglobulins: Processing, preservation and application aspects. International Dairy Journal, 85, 201–210. doi: https://doi.org/10.1016/j.idairyj.2018.05.016
Hyrslova, I., Krausova, G., Michlova, T., Kana, A., Curda, L. (2020). Fermentation Ability of Bovine Colostrum by Different Probiotic Strains. Fermentation, 6 (3), 93. doi: https://doi.org/10.3390/fermentation6030093
Pithua, P., Aly, S. S. (2013). A cohort study of the association between serum immunoglobulin G concentration and preweaning health, growth, and survival in Holstein calves. International Journal of Applied Research in Veterinary Medicine, 11 (1), 77–84.
Bozhkov, A. I., Nikitchenko, Y. V., Lebid, K. M., Ivanov, E. G., Kurguzova, N. I., Gayevoy, S. S., Al Begai M. A. Y. (2017). Low molecular weight components from various sources eliminate oxidative stress and restore physiological characteristic of animals at early stages of Cu- induced liver fibrosis development. Translational Biomedicine, 8 (2). doi: https://doi.org/10.21767/2172-0479.1000107
Bozhkov, A. I., Nikitchenko, Y. V., Klimova, E. M., Linkevych, O. S., Lebid, K. M., Al-Bahadli, A. M. M., Alsardia, M. M. A. (2017). Young and old rats have different strategies of metabolic adaptation to Cu-induced liver fibrosis. Advances in Gerontology, 7 (1), 41–50. doi: https://doi.org/10.1134/s2079057017010040
Elfstrand, L., Lindmark-Månsson, H., Paulsson, M., Nyberg, L., Åkesson, B. (2002). Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing. International Dairy Journal, 12 (11), 879–887. doi: https://doi.org/10.1016/s0958-6946(02)00089-4
Miciński, J., Miciński, J., Pogorzelska, J., Shaikamal, G. I., Sobczuk-Szul, M., Beisenov, A. et. al. (2016). Basic and mineral composition of colostrum from cows in different ages and calving period. Journal of Elementology, 22 (1), 259–269. doi: https://doi.org/10.5601/jelem.2016.21.2.1159
Kozheshkurt, V., Ivanov, I., Antonenko, Y., Katrich, V., Bozhkov, A., Gromovoy, T. (2021). Devising an express method for estimating the quality of colostrum and its components based on electrical electric conductivity. Eastern-European Journal of Enterprise Technologies, 1 (11 (109)), 69–77. doi: https://doi.org/10.15587/1729-4061.2021.225007
Asakawa, T., Matsushita, S. (1980). Coloring conditions of thiobarbituric acid test for detecting lipid hydroperoxides. Lipids, 15 (3), 137–140. doi: https://doi.org/10.1007/bf02540959
Paglia, D. E., Valentine, W. N. (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of laboratory and clinical medicine, 70 (1), 158–169.
Gramse, G., Dols-Perez, A., Edwards, M. A., Fumagalli, L., Gomila, G. (2013). Nanoscale Measurement of the Dielectric Constant of Supported Lipid Bilayers in Aqueous Solutions with Electrostatic Force Microscopy. Biophysical Journal, 104 (6), 1257–1262. doi: https://doi.org/10.1016/j.bpj.2013.02.011
Bozhkov, A. I., Linkevych, O. S., Ivanov, E. G., Klimova, O. M., Al Begai, M. A. Y. (2016). Low molecular weight components of colostrum regulate the activity of cellular component of the immune system in animals with Cu-induced liver fibrosis. International Journal of Current Research, 8 (12), 44129–44137.
Contarini, G., Povolo, M., Pelizzola, V., Monti, L., Bruni, A., Passolungo, L. et. al. (2014). Bovine colostrum: Changes in lipid constituents in the first 5 days after parturition. Journal of Dairy Science, 97 (8), 5065–5072. doi: https://doi.org/10.3168/jds.2013-7517
Coroian, A., Erler, S., Matea, C. T., Mireșan, V., Răducu, C., Bele, C., Coroian, C. O. (2013). Seasonal changes of buffalo colostrum: physicochemical parameters, fatty acids and cholesterol variation. Chemistry Central Journal, 7 (1). doi: https://doi.org/10.1186/1752-153x-7-40
Copyright (c) 2021 Ievgen Ivanov, Valentyn Kozheshkurt, Anatoly Bozhkov, Anatolii Goltvjansky, Victor Katrich, Vadim Sidorov, Taras Gromovoy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
