Investigation of biological activities of Xeromphis uliginosa (Retz.) root extracts in Swiss-albino mice model, an extinctive medicinal plant of Bangladesh

Keywords: Xeromphis uliginosa, methanolic extract, analgesic, antidepressant, antidiarrheal, hypoglycaemic, mice model

Abstract

Xeromphis. uliginosa (Retz.) is an extinctive Bangladeshi medicinal plant that is locally used for the treatments of pain, diabetes, diarrhea, depressant, and other diseases. The present study was conducted to evaluate the peripheral analgesic activity (PAA), central analgesic activity (CAA), central nervous system antidepressant activity (CNS-AD), antidiarrheal activity (ADA), and hypoglycaemic activity (HGA) of methanolic root extract of X. uliginosa (MREXU) in a mice model.

The acetic acid-induced writhing inhibition and tail flick method were applied to determine the PAA and CAA of MREXU. The CNS-AD was measured using the phenobarbitone sodium-mediated sleeping method whereas, the castor oil-induced antidiarrheal method was used to determine the ADA of the crude extracts. To determine the HGA of MREXU crude extract, the tail tipping technique was conducted in a mice model.

The MREXU displayed potential PAA and CAA in mice models. The MREXU 200 and 400 mg/kg significantly inhibit the number of writings along with diclofenac sodium. On the other hand, MREXU both doses significantly inhibit thermal stimulus after 60 and 90 minutes respectively. In the CNS-AD study, crude extract of 200 and 400 mg/kg significantly increase the onset of sleep by decreasing the duration of sleep. Similarly, the dose of 200 mg/kg significantly reduced diarrheal faeces for the whole 4 hours of experiments. The heartiest outcome of MREXU was displayed in the HGA assay. Both doses of MREXU significantly reduced the blood sugar level for the entire 3 hours of the experiments.

In this study, it is revealed that the root of MREXU has extremely significant blood sugar-reducing activity, potential CNS-AD and mild to moderate nociceptive activity in the mice model

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Author Biographies

Asma Aul Husna Pinkey, State University of Bangladesh

Department of Pharmacy

Md Zahirul Islam Khan, The Hong Kong Polytechnic University

Department of Health Technology and Informatics

Md Rashaduzzaman Razu, State University of Bangladesh

Department of Pharmacy

Farhana Sultana Mitu, Islamic University

Department of Biotechnology and Genetic Engineering

Mahfuza Afroz Soma, State University of Bangladesh

Department of Pharmacy

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Investigation of biological activities of Xeromphis uliginosa (Retz.) root extracts in Swiss-albino mice model, an extinctive medicinal plant of Bangladesh

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Published
2022-11-16
How to Cite
Pinkey, A. A. H., Islam Khan, M. Z., Razu, M. R., Mitu, F. S., & Soma, M. A. (2022). Investigation of biological activities of Xeromphis uliginosa (Retz.) root extracts in Swiss-albino mice model, an extinctive medicinal plant of Bangladesh. EUREKA: Life Sciences, (5), 18-27. https://doi.org/10.21303/2504-5695.2022.002600
Section
Biochemistry, Genetics and Molecular Biology