ASSOCIATION BETWEEN VITAMIN D-BINDING PROTEIN (VDBP) GENE POLYMORPHISM AND VITAMIN D STATUS IN YOUNG CHILDREN

Keywords: VDBP gene polymorphism, vitamin D, young children

Abstract

Object of the research: VDBP gene polymorphism.

Problem being addressed: the effect of existing polymorphic variants of the VDBP gene on the absorption of vitamin D in young children.

The main scientific results. At the beginning of the survey, vitamin D supplementation was performed in 50.0±9.1 % (15/30) of children. The concentration of 25 (OH) D in the serum of the subjects was 32.9 ng/ml (23.2–60.0). All patients with the GG rs 7041 genotype of the VDBP gene had a concentration of 25 (OH) D in the range of 20-100 ng/ml, which is statistically more common than in children with the AA rs 4588 genotype (p=0.015), GT rs 7041 genotype (p=0.047) and genotype TT rs 7041 (p=0.033). Patients with CA rs 4588 genotypes – 23.7 ng/ml (14.8-35.8) and GT rs 7041 – 28.1 ng/ml (17.1–49) had the lowest serum levels of 25 (OH) D, the highest levels of 25 (OH) D – children with genotype AA rs 4588 – 122.6 ng/ml (23.2–124.1) and genotype TT rs 7041 – 78.6 ng/ml (23.2 –124.1). Carriers of the AA rs 4588 genotype were more likely than patients with the GG rs 7041 genotype to show dangerously high levels of 25 (OH) D (p=0.069). Patients with the AA rs 4588 genotype had lower alkaline phosphatase levels compared to the GT rs 7041 and CC rs 4588 genotypes – 185.0 U/l (147.0–212.0) versus 259.5 U/l (207.0–334.5), p=0.021 and against 251.0 U/l (222.0–346.0), p=0.016.

Area of practical application of research results: The results of the study can be used by working groups to make recommendations for the prevention and treatment of vitamin D deficiency and in the practice of health care facilities.

Innovative technological product: association between allelic variants of the VDBP gene and vitamin D status in young children.

Scope of application of innovative technological product: pediatrics, medical genetics.

Conclusions. Genetic variants of VDBP may affect the absorption of vitamin D and cause variability in 25 (OH) D levels, which complicates the development of uniform recommendations for optimal prophylactic doses of vitamin D and necessitates additional research. The highest levels of 25 (OH) D were recorded in children with genotypes AA rs 4588 and TT rs 7041 of the VDBP gene, which showed high absorption when taking vitamin D supplements at a dose of 500 IU and even excessive concentrations of 25 (OH) D with long-term supplementation in higher dose.

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Author Biographies

Mariia Romanko, Shupyk National Medical Academy of Postgraduate Education

Department of Pediatrics No. 2

Iryna Maydan, State Institution «Institute of Pediatrics Obstetrics and Gynecology named Academic E. M. Lukyanova National Academy of Medical Sciences of Ukraine»

Department of Healthy Child Problems and Premorbid Conditions

Maryna Mamenko, Shupyk National Medical Academy of Postgraduate Education

Department of Pediatrics No. 2

Lyudmila Kvashnina, State Institution «Institute of Pediatrics Obstetrics and Gynecology named Academic E. M. Lukyanova National Academy of Medical Sciences of Ukraine»

Department of Healthy Child Problems and Premorbid Conditions

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Published
2020-12-30
How to Cite
Romanko, M., Rossokha, Z., Maydan, I., Mamenko, M., & Kvashnina, L. (2020). ASSOCIATION BETWEEN VITAMIN D-BINDING PROTEIN (VDBP) GENE POLYMORPHISM AND VITAMIN D STATUS IN YOUNG CHILDREN. ScienceRise, (6), 51-58. https://doi.org/10.21303/2313-8416.2020.001557
Section
Innovative technologies in healthcare