INFLUENCE OF EXOCRINE PANCREATIC INSUFFICIENCY ON THE COURSE OF TYPE 2 DIABETES MELLITUS IN PATIENTS WITH PRIMARY OSTEOARTHRITIS

Keywords: primary osteoarthritis, chronic pancreatitis, type 2 diabetes mellitus

Abstract

The study of the functional capacity of the pancreas in chronic pancreatitis (CP) in comorbidity with type 2 diabetes mellitus (DM2) and primary osteoarthritis (OA) is also relevant given that patients with this combination are associated with the presence of metabolic syndrome.

The aim of the study was to investigate the state of functional capacity of the pancreas in patients with comorbid chronic pancreatitis and type 2 diabetes mellitus with osteoarthritis.

Material and methods. 117 patients with CP with OA with concomitant DM2 and without it were studied. The main group consisted of 92 outpatients with CP with OA in combination with diabetes in the phase of stable or unstable remission, the comparison group – 25 patients with isolated CP with primary OA, and the control group – 30 healthy individuals. Diagnoses of OA, CP and DM2 were established according to generally accepted criteria and protocols

Results. Analysis of the data showed that on average in the contingent of studied patients with comorbid OA, CP and DM2 excretory insufficiency of pancreas was significantly more severe than in the group of patients with isolated CP with OA.

Conclusions. In the combined course of CP and DM2 with OA, the correlation between fecal α-elastase-1 and glycosylated hemoglobin was statistically significantly stronger than in the group of patients with isolated CP, indicating a mutually aggravating effect of CP and DM2.

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Author Biographies

Liliya Babinets, I. Horbachevsky Ternopil National Medical University

Department of Primary Health Care and General Practice - Family Medicine

Iryna Halabitska, I. Horbachevsky Ternopil National Medical University

Department of Microbiology, Virology and Immunology

References

Babinets, L. S., Halabitska, I. M., Kotsaba, Y. Y., Borovyk, I. O., Migenko, B. O., Ryabokon, S. S., Tsybulska, L. S. (2018). The effect of the proteolisis' system activity for the trophological status of patients with osteoarthrosis and excretory insufficiency of pancreas. Wiadomosci Lekarskie (Warsaw, Poland : 1960), 71 (2), 273–276.

Tavakoli Nia, H., Han, L., Soltani Bozchalooi, I., Roughley, P., Youcef-Toumi, K., Grodzinsky, A. J., Ortiz, C. (2015). Aggrecan Nanoscale Solid–Fluid Interactions Are a Primary Determinant of Cartilage Dynamic Mechanical Properties. ACS Nano, 9 (3), 2614–2625. doi: http://doi.org/10.1021/nn5062707

Glyn-Jones, S., Palmer, A. J. R., Agricola, R., Price, A. J., Vincent, T. L., Weinans, H., Carr, A. J. (2015). Osteoarthritis. The Lancet, 386 (9991), 376–387. doi: http://doi.org/10.1016/s0140-6736(14)60802-3

Waldstein, W., Perino, G., Gilbert, S. L., Maher, S. A., Windhager, R., Boettner, F. (2015). OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee. Journal of Orthopaedic Research, 34 (1), 135–140. doi: http://doi.org/10.1002/jor.23010

Kothari, D., Ketwaroo, G., Freedman, S. D., Sheth, S. G. (2017). The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing. Pancreas, 46 (7), 887–890. doi: http://doi.org/10.1097/mpa.0000000000000871

Lévy, P., Domínguez-Muñoz, E., Imrie, C., Löhr, M., Maisonneuve, P. (2014). Epidemiology of chronic pancreatitis: burden of the disease and consequences. United European Gastroenterology Journal, 2 (5), 345–354. doi: http://doi.org/10.1177/2050640614548208

Lew, D., Afghani, E., Pandol, S. (2017). Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment. Digestive Diseases and Sciences, 62 (7), 1702–1712. doi: http://doi.org/10.1007/s10620-017-4602-2

Löhr, J.-M., Oliver, M. R., Frulloni, L. (2013). Synopsis of recent guidelines on pancreatic exocrine insufficiency. United European Gastroenterology Journal, 1 (2), 79–83. doi: http://doi.org/10.1177/2050640613476500

Wang, X., Hunter, D., Xu, J., Ding, C. (2015). Metabolic triggered inflammation in osteoarthritis. Osteoarthritis and Cartilage, 23 (1), 22–30. doi: http://doi.org/10.1016/j.joca.2014.10.002

Singh, J. A., Noorbaloochi, S., MacDonald, R., Maxwell, L. J. (2015). Chondroitin for osteoarthritis. Cochrane Database of Systematic Reviews. doi: http://doi.org/10.1002/14651858.cd005614.pub2


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Published
2020-10-29
How to Cite
Babinets, L., & Halabitska, I. (2020). INFLUENCE OF EXOCRINE PANCREATIC INSUFFICIENCY ON THE COURSE OF TYPE 2 DIABETES MELLITUS IN PATIENTS WITH PRIMARY OSTEOARTHRITIS. Technology Transfer: Innovative Solutions in Medicine, 21-23. https://doi.org/10.21303/2585-663.2020.001488
Section
Medicine and Dentistry