INFLUENCE OF EXOCRINE PANCREATIC INSUFFICIENCY ON THE COURSE OF TYPE 2 DIABETES MELLITUS IN PATIENTS WITH PRIMARY OSTEOARTHRITIS
The study of the functional capacity of the pancreas in chronic pancreatitis (CP) in comorbidity with type 2 diabetes mellitus (DM2) and primary osteoarthritis (OA) is also relevant given that patients with this combination are associated with the presence of metabolic syndrome.
The aim of the study was to investigate the state of functional capacity of the pancreas in patients with comorbid chronic pancreatitis and type 2 diabetes mellitus with osteoarthritis.
Material and methods. 117 patients with CP with OA with concomitant DM2 and without it were studied. The main group consisted of 92 outpatients with CP with OA in combination with diabetes in the phase of stable or unstable remission, the comparison group – 25 patients with isolated CP with primary OA, and the control group – 30 healthy individuals. Diagnoses of OA, CP and DM2 were established according to generally accepted criteria and protocols
Results. Analysis of the data showed that on average in the contingent of studied patients with comorbid OA, CP and DM2 excretory insufficiency of pancreas was significantly more severe than in the group of patients with isolated CP with OA.
Conclusions. In the combined course of CP and DM2 with OA, the correlation between fecal α-elastase-1 and glycosylated hemoglobin was statistically significantly stronger than in the group of patients with isolated CP, indicating a mutually aggravating effect of CP and DM2.
Babinets, L. S., Halabitska, I. M., Kotsaba, Y. Y., Borovyk, I. O., Migenko, B. O., Ryabokon, S. S., Tsybulska, L. S. (2018). The effect of the proteolisis' system activity for the trophological status of patients with osteoarthrosis and excretory insufficiency of pancreas. Wiadomosci Lekarskie (Warsaw, Poland : 1960), 71 (2), 273–276.
Tavakoli Nia, H., Han, L., Soltani Bozchalooi, I., Roughley, P., Youcef-Toumi, K., Grodzinsky, A. J., Ortiz, C. (2015). Aggrecan Nanoscale Solid–Fluid Interactions Are a Primary Determinant of Cartilage Dynamic Mechanical Properties. ACS Nano, 9 (3), 2614–2625. doi: http://doi.org/10.1021/nn5062707
Glyn-Jones, S., Palmer, A. J. R., Agricola, R., Price, A. J., Vincent, T. L., Weinans, H., Carr, A. J. (2015). Osteoarthritis. The Lancet, 386 (9991), 376–387. doi: http://doi.org/10.1016/s0140-6736(14)60802-3
Waldstein, W., Perino, G., Gilbert, S. L., Maher, S. A., Windhager, R., Boettner, F. (2015). OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee. Journal of Orthopaedic Research, 34 (1), 135–140. doi: http://doi.org/10.1002/jor.23010
Kothari, D., Ketwaroo, G., Freedman, S. D., Sheth, S. G. (2017). The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing. Pancreas, 46 (7), 887–890. doi: http://doi.org/10.1097/mpa.0000000000000871
Lévy, P., Domínguez-Muñoz, E., Imrie, C., Löhr, M., Maisonneuve, P. (2014). Epidemiology of chronic pancreatitis: burden of the disease and consequences. United European Gastroenterology Journal, 2 (5), 345–354. doi: http://doi.org/10.1177/2050640614548208
Lew, D., Afghani, E., Pandol, S. (2017). Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment. Digestive Diseases and Sciences, 62 (7), 1702–1712. doi: http://doi.org/10.1007/s10620-017-4602-2
Löhr, J.-M., Oliver, M. R., Frulloni, L. (2013). Synopsis of recent guidelines on pancreatic exocrine insufficiency. United European Gastroenterology Journal, 1 (2), 79–83. doi: http://doi.org/10.1177/2050640613476500
Wang, X., Hunter, D., Xu, J., Ding, C. (2015). Metabolic triggered inflammation in osteoarthritis. Osteoarthritis and Cartilage, 23 (1), 22–30. doi: http://doi.org/10.1016/j.joca.2014.10.002
Singh, J. A., Noorbaloochi, S., MacDonald, R., Maxwell, L. J. (2015). Chondroitin for osteoarthritis. Cochrane Database of Systematic Reviews. doi: http://doi.org/10.1002/14651858.cd005614.pub2
Copyright (c) 2020 Liliya Babinets, Iryna Halabitska
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the CREATIVE COMMONS copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons Attribution License, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.