Biochemical status of blood of dogs with atopic dermatitis in the conditions of private veterinary clinic “Alfa vet” m. Konotop
Metabolic changes in the body of dogs with atopic dermatitis and the causes of its occurrence still remain poorly understood. This study confirms the need for biochemical blood tests for the differential diagnosis of skin diseases in animals.
The aim of the research. To identify metabolic changes in dogs with atopic dermatitis.
Methods. Serum samples from five ill animals and five intact animals were tested. The diagnosis of the nosological form of skin lesions was established based on the results of anamnesis and clinical manifestations of the disease. Additionally, biochemical studies of the serum of sick animals were performed. Blood of dogs (n=5) was taken from the anterior subcutaneous vein of the forearm or the lateral subcutaneous vein of the tibia into blood tubes.
Results. In the study of mineral metabolism, it was found that the concentration of inorganic phosphorus in the serum of sick animals is reduced by only 0.01 mmol/l, but the concentration of total calcium by 10.0 %. The concentration of cholesterol increases 1.3 times and exceeds the reference values by 0.16 mmol/l. In the blood of sick animals, the activity of alanine aminotransferase is significantly reduced by 21.0 % and aspartate aminotransferase – by 20.0 % compared to intact animals. The enzyme gamma-glutamyltransferase probably increases by 1.51 times (P<0.05) in sick dogs, but does not exceed the reference values.
Conclusions. It was found that in atopic dermatitis in the serum of dogs decreases the activity of alanine aminotransferase by 21.0 % and aspartate aminotransferase – by 20.0 %, while the activity of gamma-glutamyltransferase increases 1.51 times. The results show the toxic effect of an allergic agent on animals, especially on the liver, which confirms the previous diagnosis – atopic dermatitis.
Majewska, A., Gajewska, M., Dembele, K., Maciejewski, H., Prostek, A., Jank, M. (2016). Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis. BMC Veterinary Research, 12 (1). doi: http://doi.org/10.1186/s12917-016-0805-6
Gedon, N. K. Y., Mueller, R. S. (2018). Atopic dermatitis in cats and dogs: a difficult disease for animals and owners. Clinical and Translational Allergy, 8 (1). doi: http://doi.org/10.1186/s13601-018-0228-5
Marsella, R. (2021). Atopic Dermatitis in Domestic Animals: What Our Current Understanding Is and How This Applies to Clinical Practice. Veterinary Sciences, 8 (7), 124. doi: http://doi.org/10.3390/vetsci8070124
Anturaniemi, J., Zaldívar-López, S., Savelkoul, H. F. J., Elo, K., Hielm-Björkman, A. (2020). The Effect of Atopic Dermatitis and Diet on the Skin Transcriptome in Staffordshire Bull Terriers. Frontiers in Veterinary Science, 7. doi: http://doi.org/10.3389/fvets.2020.552251
Hensel, P., Santoro, D., Favrot, C., Hill, P., Griffin, C. (2015). Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification. BMC Veterinary Research, 11 (1). doi: http://doi.org/10.1186/s12917-015-0515-5
Lee, H. M., Park, I. H., Shin, J. M., Yoon, H. S., Park, G. Y., Zeher, M. et. al. (2016). XXIV World Allergy Congress 2015. The World Allergy Organization Journal, 9 (Suppl 1), 14. doi: http://doi.org/10.1186/s40413-016-0096-1
Abstracts TPS (2019). Allergy, 74 (S106), 376–853. doi: http://doi.org/10.1111/all.13961
Nuttall, T., Reece, D., Roberts, E. (2014). Life-long diseases need life-long treatment: long-term safety of ciclosporin in canine atopic dermatitis. Veterinary Record, 174 (S2), 3–12. doi: http://doi.org/10.1136/vr.102471
Rynhoud, H., Gibson, J. S., Meler, E., Soares Magalhães, R. J. (2021). The Association Between the Use of Oclacitinib and Antibacterial Therapy in Dogs With Allergic Dermatitis: A Retrospective Case-Control Study. Frontiers in Veterinary Science, 8. doi: http://doi.org/10.3389/fvets.2021.631443
Olivry, T., DeBoer, D. J., Favrot, C., Jackson, H. A., Mueller, R. S. et. al. (2015). Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Veterinary Research, 11 (1). doi: http://doi.org/10.1186/s12917-015-0514-6
Allaway, D., Kamlage, B., Gilham, M. S., Hewson-Hughes, A. K., Wiemer, J. C., Colyer, A., Rein, D. (2013). Effects of dietary glucose supplementation on the fasted plasma metabolome in cats and dogs. Metabolomics, 9 (5), 1096–1108. doi: http://doi.org/10.1007/s11306-013-0527-8
Gao, X., Chen, W., Li, R., Wang, M., Chen, C., Zeng, R., Deng, Y. (2012). Systematic variations associated with renal disease uncovered by parallel metabolomics of urine and serum. BMC Systems Biology, 6 (S1). doi: http://doi.org/10.1186/1752-0509-6-s1-s14
Kaddurah-Daouk, R., Kristal, B. S., Weinshilboum, R. M. (2008). Metabolomics: A Global Biochemical Approach to Drug Response and Disease. Annual Review of Pharmacology and Toxicology, 48 (1), 653–683. doi: http://doi.org/10.1146/annurev.pharmtox.48.113006.094715
Gibney, M. J. (2018). Ultra-Processed Foods: Definitions and Policy Issues. Current Developments in Nutrition, 3 (2). doi: http://doi.org/10.1093/cdn/nzy077
Tobie, C., Péron, F., Larose, C. (2015). Assessing Food Preferences in Dogs and Cats: A Review of the Current Methods. Animals, 5 (1), 126–137. doi: http://doi.org/10.3390/ani5010126
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