Peculiarities of surgical tactics of patients with thymus tumors

Keywords: thymoma, surgical treatment, postoperation complication, radical surgery, bypass, vena cava superior syndrome, classification of thymomas, diagnostics, Myasthenia gravis

Abstract

The aim of the study: to study retrospective analysis results of the surgical treatment of thymus tumours for predicting long-time results.

Methods. Study included 35 patients who were treated at the Department of Thoraco-abdominal Surgery from September 2019 to May 2021. The control group included 20 patients with SVCS were treated with conventional techniques, while the experimental group included 15 patients who underwent a novel bypass surgery developed by us.

Results. The venous bypass was mandatorily complemented with cytoreduction. Complications in the post-operative period were reported from the experimental group and included auriculo-subclavian bypass thrombosis, post-operative complications were reported in the control group including haemorrhage from the sternotomy wound in 1 (3.3 %) case, superior vena cava thrombosis in 2 (6.6 %) cases, pneumonia in 2 (6.6 %). The relative risk of complications and lethal outcome was calculated for patients from both groups. It was found that the risk of complications was twice as high in the control group as in the experimental group (standard error of relative risk equals 0.64).

Conclusion. The first mandatory step of the radical surgery in patients with thymomas with SVC invasion should be the auriculo-jugular and auriculo-subclavian bypasses, which can reduce the relative risk of post-operative complications by a factor of the risk of lethal by a factor of 3.5

Downloads

Download data is not yet available.

Author Biography

Kateryna Ponomarova, Kharkiv National Medical University

Department Surgery No. 1

References

Michels, G., Drebber, U., Pfister, R., Michels, G. (2012). Thymoma – an important differential diagnosis of mediastinal tumours. Acta Clinical, 67 (4), 304–305.

Girard, N., Ruffini, E., Marx, A., Faivre-Finn, C., Peters, S. (2015). Thymic epithelial tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 26, v40–v55. doi: http://doi.org/10.1093/annonc/mdv277

Klimova, E. M., Drozdova, L. A., Lavinskaya, E. V., Minukhin, D. V., Kudrevich, A. N. (2020). Advisability of thymectomy in young patients with thymus-independent myasthenia gravis in the presence of biomarkers specific for patients with thymoma. Kharkiv Surgical School, 3, 62–67. doi: http://doi.org/10.37699/2308-7005.3.2020.13

Boyko, V. V., Klimova, O. M., Lavinskaya, O. V., Drozdova, L. A., Minukhin, D. V., Yevtushenko, D. O. (2019). The Choice of Treatment in Various Ages Patients with Myasthenia Against to Immuneresistance Parameters. International Journal of Education and Science, 2 (3), 43–52. doi: http://doi.org/10.26697/ijes.2019.3.4

Barbolina, T. D., Bychkov, M. B., Allakhverdiev, A. K., Borisova, T. N., Vladimirova, L. Iu., Gerasimov, S. S. et. al. (2021). Prakticheskie rekomendatsii po lekarstvennomu lecheniiu opukholei vilochkovoi zhelezy (timomy i raka timusa). Malignant Tumours, 10 (3s2-1), 603–614. doi: http://doi.org/10.18027/2224-5057-2020-10-3s2-35

Rouquette, I., Taranchon-Clermont, E., Gilhodes, J., Bluthgen, M.-V., Perallon, R., Chalabreysse, L. et. al. (2019). Immune biomarkers in thymic epithelial tumors: expression patterns, prognostic value and comparison of diagnostic tests for PD-L1. Biomarker Research, 7 (1). doi: http://doi.org/10.1186/s40364-019-0177-8

Alexandrov, O. A., Ryabov, A. B., Pikin, O. V. (2017). Thymoma (review of the literature). Siberian Journal of Oncology, 16 (4), 76–83. doi: http://doi.org/10.21294/1814-4861-2017-16-4-76-83

Boyko, V., Krasnoyaruzhskyi, A., Minukhin, D., Dubovyk, D., Ponomarova, K., Sochnieva, A., Kritsak, V. (2021). Outcomes of surgical reconstruction of the superior vena cava syndrome in patients with locally advanced thymomas. EUREKA: Health Sciences, 3, 37–44. doi: http://doi.org/10.21303/2504-5679.2021.001852

Tovazhnyanska, O. L., Klimova, O. M., Samoilova, H. P., Minukhin, D. V., Ponomarova, K. V., Yevtushenko, D. O., Hroma, V. G. (2021). Rehabilitation of the patients with myasthenia gravis as an Integral part of the patient’s Treatment Algorithm in the postoperative period. Acta Balneologica, 64 (3), 155–159. doi: http://doi.org/10.36740/abal202103104

Kritsak, V., Ponomarova, K., Minukhin, D. (2020). Preoperative endobronchial sanitation as preparation for thoracic interventions. EUREKA: Health Sciences, 2, 46–52. doi: http://doi.org/10.21303/2504-5679.2020.001188

Nam, J. G., Goo, J. M., Park, C. M., Lee, H., Lee, C. H., Yoon, S. H. (2019). Age‐ and gender‐specific disease distribution and the diagnostic accuracy of CT for resected anterior mediastinal lesions. Thoracic Cancer, 10 (6), 1378–1387. doi: http://doi.org/10.1111/1759-7714.13081


👁 28
⬇ 15
Published
2021-10-29
How to Cite
Ponomarova, K. (2021). Peculiarities of surgical tactics of patients with thymus tumors. Technology Transfer: Innovative Solutions in Medicine, 7-9. https://doi.org/10.21303/2585-6634.2021.002150
Section
Medicine and Dentistry