Synthesize and characterization of artificial human bone developed by using nanocomposite
The combination of biopolymers with bioceramics plays vital role in development of artificial bone. Hydroxyapatite is extensively used as a material in prosthetic bone repair and replacement. In this paper synthesis of Hydroxyapatite- Polymethyl methacrylate – Zirconia (Hap-PMMA-ZrO2) composite by using powder metallurgy technique. The mechanical, morphological, In-vitro biocompatibility and tribological properties were characterized by universal testing machine, micro-vickers hardness tester, high resolution transmission electron microscope (HR-TEM), MTT assay and pin-on-disc setup. In-vitro cytotoxicity test on HeLa cell lines shows cell viability constant when doses concentration increases so material found non-toxic. Results show that micro Vickers hardness i.e. 520 approximately matches with natural human bone i.e. 400. Compressive strength is less as compared to human bone because of powder metallurgy route used for fabrication and is 74 MPa. Density of proposed composite artificial human bone i.e. 1.52 g/cc is less as compared to natural bone i.e. 2.90 g/cc. The Hap-PMMA-ZrO2 composite will be good biomaterials for bone repair and replacement work
Deng, M., James, R., Laurencin, C. T., Kumbar, S. G. (2012). Nanostructured Polymeric Scaffolds for Orthopaedic Regenerative Engineering. IEEE Transactions on NanoBioscience, 11 (1), 3–14. doi: https://doi.org/10.1109/tnb.2011.2179554
Hench, L. L. (2005). Bioceramics. Journal of the American Ceramic Society, 81 (7), 1705–1728. doi: https://doi.org/10.1111/j.1151-2916.1998.tb02540.x
Luo, D., Sang, L., Wang, X., Xu, S., Li, X. (2011). Low temperature, pH-triggered synthesis of collagen–chitosan–hydroxyapatite nanocomposites as potential bone grafting substitutes. Materials Letters, 65 (15-16), 2395–2397. doi: https://doi.org/10.1016/j.matlet.2011.05.011
De Groot, K., Klein, C. P. A. T., Wolke, J. G. C., de Blieck-Hogervorst, J. (1990). Chemistry of Calcium Phosphate Bioceramics. Handbook of Bioactive Ceramics, Vol. II. Calcium Phosphate and Hydroxylapatite Ceramics. Boca Raton, FL, 3–15.
Ding, S.-J., Chu, Y.-H., Wang, D.-Y. (2017). Enhanced properties of novel zirconia-based osteo-implant systems. Applied Materials Today, 9, 622–632. doi: https://doi.org/10.1016/j.apmt.2017.09.007
Tanaka, Y., Hirata, Y., Yoshinaka, R. (2003). Synthesis and Characteristics of Ultrafine Hydroxyapatite Particles. Journal of Ceramic Processing Research, 4 (4), 197–201. Available at: https://www.researchgate.net/publication/290822378_Synthesis_and_characteristics_of_ultrafine_hydroxyapatite_particles
Casati, R., Vedani, M. (2014). Metal Matrix Composites Reinforced by Nano-Particles – A Review. Metals, 4 (1), 65–83. doi: https://doi.org/10.3390/met4010065
Liu, W., Su, P., Gonzales, A., Wang, N., Zhang, Z., Li, H. et. al. (2015). Optimizing stem cell functions and antibacterial properties of TiO2 nanotubes incorporated with ZnO nanoparticles: experiments and modeling. International Journal of Nanomedicine, 1997. doi: https://doi.org/10.2147/ijn.s74418
Hetrick, E. M., Schoenfisch, M. H. (2006). Reducing implant-related infections: active release strategies. Chemical Society Reviews, 35 (9), 780. doi: https://doi.org/10.1039/b515219b
Labieniec, M., Gabryelak, T. (2003). Effects of tannins on Chinese hamster cell line B14. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 539 (1-2), 127–135. doi: https://doi.org/10.1016/s1383-5718(03)00161-x
Lapshina, E. A., Zavodnik, I. B., Labieniec, M., Rękawiecka, K., Bryszewska, M. (2005). Cytotoxic and genotoxic effects of tert-butyl hydroperoxide on Chinese hamster B14 cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 583 (2), 189–197. doi: https://doi.org/10.1016/j.mrgentox.2005.03.005
Jin, Z., Dowson, D. (2013). Bio-friction. Friction, 1 (2), 100–113. doi: https://doi.org/10.1007/s40544-013-0004-4
Bandgar, S. S., Kolekar, T. V., Shirguppikar, S. S., Shinde, M. A., Shejawal, R. V., Bamane, S. R. (2017). Synthesis, characterization of silver doped hydroxyapatite nanoparticles for biomedical applications. Der Pharma Chemica, 9 (3), 78–84. Available at: https://www.derpharmachemica.com/pharma-chemica/synthesis-characterization-of-silver-doped-hydroxyapatite-nanoparticles-for-biomedical-applications.pdf
Copyright (c) 2022 Pham Van Dong, Santosh R. Patil, Shailesh S. Shirguppikar, Do Ngoc Tu, Nguyen Huu Phan, Le Thi Phuong Thanh, Ngo Ngoc Vu
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.