@article{Dong_Patil_Shirguppikar_Tu_Phan_Thanh_Vu_2022, title={Synthesize and characterization of artificial human bone developed by using nanocomposite}, url={https://journal.eu-jr.eu/engineering/article/view/2432}, DOI={10.21303/2461-4262.2022.002432}, abstractNote={<p>The combination of biopolymers with bioceramics plays vital role in development of artificial bone. Hydroxyapatite is extensively used as a material in prosthetic bone repair and replacement. In this paper synthesis of Hydroxyapatite- Polymethyl methacrylate – Zirconia (Hap-PMMA-ZrO2) composite by using powder metallurgy technique. The mechanical, morphological, In-vitro biocompatibility and tribological properties were characterized by universal testing machine, micro-vickers hardness tester, high resolution transmission electron microscope (HR-TEM), MTT assay and pin-on-disc setup. In-vitro cytotoxicity test on HeLa cell lines shows cell viability constant when doses concentration increases so material found non-toxic. Results show that micro Vickers hardness i.e. 520&nbsp;approximately matches with natural human bone i.e.&nbsp;400. Compressive strength is less as compared to human bone because of powder metallurgy route used for fabrication and is 74&nbsp;MPa. Density of proposed composite artificial human bone i.e. 1.52&nbsp;g/cc is less as compared to natural bone i.e. 2.90&nbsp;g/cc. The Hap-PMMA-ZrO2 composite will be good biomaterials for bone repair and replacement work</p&gt;}, number={3}, journal={EUREKA: Physics and Engineering}, author={Dong, Pham Van and Patil, Santosh R. and Shirguppikar, Shailesh S. and Tu, Do Ngoc and Phan, Nguyen Huu and Thanh, Le Thi Phuong and Vu, Ngo Ngoc}, year={2022}, month={May}, pages={112-120} }