SELECTION OF FLAVOUR ADDITIVES AND METHOD OF THEIR INTRODUCTION IN THE COMPOSITION OF COMPRESSED MEDICATED CHEWING GUMS

Keywords: medicated chewing gums, flavours, adsorbents, organoleptic methods of coregents evaluation, physicochemical and technological research

Abstract

An important characteristic of oral medicines, which include medicated chewing gums, is their pleasant taste. This can be achieved by adding taste coregents to their composition.

The aim: to choose rational flavour additives and justify the method of their introduction to the compressed medicated chewing gums that are being developed.

Materials and methods: mint (Natural Mint Flavor SD, Kerry Inc., Malaysia), apple (Nat Apple FlavorWonf, Kerry Inc., Malaysia) and banana (Banana FLV, Kerry Inc., Malaysia) have been used as powdered flavour additives. As flavourings – oil solutions: Peppermint Natural WonfFlavor, Kerry Inc., Malaysia), Apple (Nat Apple FlavorWonf, Kerry Inc., Malaysia), Strawberry (Strawberry FlavorWonf, Kerry Inc., Malaysia), Melon (Chemical-Food Aromatic PlantLLC, Russian Federation) and Lemon (Chemical-Food Aromatic Plant LLC, Russian Federation). Aerosil brand 380 (Evonik Resource Efficiency GmbH, Germany), Syloid® 244FP (Grace Discovery Sciences, USA) and Neusilin® ULP 2 (Fuji Chemical Industry Co. Ltd, Japan) have been taken as carriers. The choice of flavour additives and flavourings was made using organoleptic methods of coregents evaluation according to A. I. Tentsova and I. A.Yegorov. The technological and physicochemical properties of the samples were studied according to conventional methods of the State Pharmacopoeia of Ukraine.

Results and discussion. In determining the taste of medicated chewing gums samples with different coregents, the combination of powder additive and liquid flavouring "Apple" has got the highest mark. In order to substantiate the rational method of liquid flavouring introduction in the composition of the compressed chewing gums, it is proposed to introduce the adsorbents Aerosil 380, Syloid® 244FP and Neusilin® ULP 2, which also play the role of moisture regulators and glidants. Microscopic analysis of adsorbents mixtures with flavouring, as well as physicochemical and technological investigations of the mass for pressing have revealed that the best adsorbing, moisture-regulating and flow properties has Syloid® 244FP.

Conclusions. As a coregent in medicated chewing gums was selected a combination of powdered (2.0 %) and liquid (0.6 %) flavours “Apple”. The method of introducing the oil flavouring into the composition of the compressed gums has been chosen – by spraying on the adsorbent with subsequent mixing. Based on the studies, Syloid®244FP at a concentration of 1.0 % was chosen as the rational carrier.

Downloads

Download data is not yet available.

Author Biographies

Yuliia Maslii, National University of Pharmacy

Department of Industrial Technology of Drugs

Оlena Ruban, National University of Pharmacy

Department of Industrial Technology of Drugs

Sergiy Kutsenko, National University of Pharmacy
Department of Industrial Technology of Drugs

References

Al Hagbani, T., Nazzal, S. (2018). Medicated Chewing Gums (MCGs): Composition, Production, and Mechanical Testing. AAPS PharmSciTech, 19 (7), 2908–2920. doi: http://doi.org/10.1208/s12249-018-1123-z

Aslani, A., Rostami, F. (2015). Medicated chewing gum, a novel drug delivery system. Journal of research in medical sciences, 20 (4), 403–411.

Shmidt, R., Tevs, G. (Eds.) (2012). Vkus i obonianie. Fiziologiia cheloveka. Vol. 1. Moscow: Mir, 304–311.

Ruban, O. A. et. al.; Pertseva, I. M. (Ed.) (2016). Dopomizhni rechovyny u vyrobnytstvi likiv. Kharkiv: Zoloti storinky, 720.

Chattopadhyay, S., Raychaudhuri, U., Chakraborty, R. (2011). Artificial sweeteners – a review. Journal of Food Science and Technology, 51 (4), 611–621. doi: http://doi.org/10.1007/s13197-011-0571-1

Council of Europe. European Pharmacopoeia (2016). Strasbourg: Council of Europe. Available at: https://www.coe.int/en/web/portal/-/the-9th-edition-european-pharmacopoeia-maintaining-high-quality-standards-in-a-dynamic-global-environment

The United States Pharmacopeia 39 – NationalFormulary 34 (2016). Washington: The United States Pharmacopeial Convention. Available at: https://www.worldcat.org/title/united-states-pharmacopeia-the-national-formulary/oclc/933365422

DSTU-N CODEXSTAN 192:2014 Kharchovi dobavky. Nomenklatura ta zahalni vymohy (CODEXSTAN 192-1995, Rev.9-2008, IDT), 246.

Maslii, Y., Ruban, O., Kolisnyk, T. (2019). Investigations with the aim of obtaining a mass for pressing medicated chewing gums “Lysodent C.” ScienceRise: Pharmaceutical Science, 3 (19), 11–16. doi: http://doi.org/10.15587/2519-4852.2019.172272

Rowe, R. C., Sheskey, P. J., Quinn, M. E. (Eds.) (2009). Sucralose. In Handbook ofPharmaceutical Excipients. London: Pharmaceutical Press and American Pharmacists Association, 701–703.

Maslii, Y. S., Ruban, O. A., Kovalevska, І. V. (2019). The choice of intense sweetener in the composition of medicated chewing gum under development. Farmatsevtychnyi Zhurnal, 5-6, 70–79. doi: http://doi.org/10.32352/0367-3057.5-6.18.05

Belmar, J., Ribé, M. (2013). Eye on Excipients. Health in Gum by Cafosa. Barcelona. As appeared in Tablets & Capsules. Available at: http://www.healthingum.com/pdf/Eye %20on %20excipients.pdf

Cafosa Health Reshenyia na bazezhevatelnoi rezynky dlia zdorovia y khoroshoho samochuvstvyia. Available at: http://www.cafosa.comor; http://www.healthingum.com.

Anurova, M. N., Bakhrushina, E. O., Pyatigorskaia, N. V., Yambikova, O. M. (2015). The principles of taste masking of oralgels with synthetic drugs. Pharmacy & Pharmacology, 4 (11), 15–20. doi: http://doi.org/10.19163/2307-9266-2015-3-4(11)-15-20

Anurova, M. N., Bakhrushina, E. O., Demina, N. B. (2015). Problemy korrektsii organolepticheskikh svoistv lekarstvennykh preparatov. Razrabotka i registratsiia lekarstvennykh sredstv, 4 (13), 64–73.

Derzhavna Farmakopeia Ukrainy. T. 1. (2015). Kharkiv: Derzhavne pidpryiemstvo «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv», 1128.

Sharma, D., Kumar, D., Singh, M. (2012). Taste masking technologies: a novel approach for the improvement of the organoleptic property of pharmaceutical active substance. International research journal of pharmacy, 3 (4), 108–116.

Rowe, R. C., Sheskey, P. J., Quinn, M. E. (Eds.) (2009). Colloidal Silicon Dioxide (Syloid). Handbook of Pharmaceutical Excipients. London: Pharmaceutical Press and American Pharmacists Association, 185–188.

Rowe, R. C., Sheskey, P. J., Quinn, M. E. (Eds.) (2009). Magnesium Aluminum Silicate (Neusilin). Handbook ofPharmaceutical Excipients. London: Pharmaceutical Press and American Pharmacists Association, 393–396.

Choudhari, Y., Reddy, U., Monsuur, F. (2016). Silikageli Syloid®FP – vspomogatelnye veschestva v proizvodstve tabletok. Afi i vspomogatelnye veschestva, 3 (264), 42–46.

Ingredienty dlia farmatsii. Neusilin® (2014). Farmatsevticheskaia otrasl, 5 (46), 25–27.

Swain, S., Patra, C. N., Bhanoji Rao, M. E. (Eds.) (2016). Pharmaceutical Drug Delivery Systems and Vehicles. India: Woodhead Publishing India Pvt. Ltd., 209–210.

Gumaste, S. G., Pawlak, S. A., Dalrymple, D. M., Nider, C. J., Trombetta, L. D., Serajuddin, A. T. M. (2013). Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates. Pharmaceutical Research, 30 (12), 3170–3185. doi: http://doi.org/10.1007/s11095-013-1114-4

Hentzschel, C. M., Alnaief, M., Smirnova, I., Sakmann, A., Leopold, C. S. (2011). Tableting properties of silica aerogel and other silicates. Drug Development and Industrial Pharmacy, 38 (4), 462–467. doi: http://doi.org/10.3109/03639045.2011.611806


👁 292
⬇ 152
Published
2020-03-31
How to Cite
Maslii, Y., RubanО., & Kutsenko, S. (2020). SELECTION OF FLAVOUR ADDITIVES AND METHOD OF THEIR INTRODUCTION IN THE COMPOSITION OF COMPRESSED MEDICATED CHEWING GUMS. EUREKA: Health Sciences, (2), 59-66. https://doi.org/10.21303/2504-5679.2020.001189
Section
Pharmacology, Toxicology and Pharmaceutical Science