SELECTION OF FLAVOUR ADDITIVES AND METHOD OF THEIR INTRODUCTION IN THE COMPOSITION OF COMPRESSED MEDICATED CHEWING GUMS
An important characteristic of oral medicines, which include medicated chewing gums, is their pleasant taste. This can be achieved by adding taste coregents to their composition.
The aim: to choose rational flavour additives and justify the method of their introduction to the compressed medicated chewing gums that are being developed.
Materials and methods: mint (Natural Mint Flavor SD, Kerry Inc., Malaysia), apple (Nat Apple FlavorWonf, Kerry Inc., Malaysia) and banana (Banana FLV, Kerry Inc., Malaysia) have been used as powdered flavour additives. As flavourings – oil solutions: Peppermint Natural WonfFlavor, Kerry Inc., Malaysia), Apple (Nat Apple FlavorWonf, Kerry Inc., Malaysia), Strawberry (Strawberry FlavorWonf, Kerry Inc., Malaysia), Melon (Chemical-Food Aromatic PlantLLC, Russian Federation) and Lemon (Chemical-Food Aromatic Plant LLC, Russian Federation). Aerosil brand 380 (Evonik Resource Efficiency GmbH, Germany), Syloid® 244FP (Grace Discovery Sciences, USA) and Neusilin® ULP 2 (Fuji Chemical Industry Co. Ltd, Japan) have been taken as carriers. The choice of flavour additives and flavourings was made using organoleptic methods of coregents evaluation according to A. I. Tentsova and I. A.Yegorov. The technological and physicochemical properties of the samples were studied according to conventional methods of the State Pharmacopoeia of Ukraine.
Results and discussion. In determining the taste of medicated chewing gums samples with different coregents, the combination of powder additive and liquid flavouring "Apple" has got the highest mark. In order to substantiate the rational method of liquid flavouring introduction in the composition of the compressed chewing gums, it is proposed to introduce the adsorbents Aerosil 380, Syloid® 244FP and Neusilin® ULP 2, which also play the role of moisture regulators and glidants. Microscopic analysis of adsorbents mixtures with flavouring, as well as physicochemical and technological investigations of the mass for pressing have revealed that the best adsorbing, moisture-regulating and flow properties has Syloid® 244FP.
Conclusions. As a coregent in medicated chewing gums was selected a combination of powdered (2.0 %) and liquid (0.6 %) flavours “Apple”. The method of introducing the oil flavouring into the composition of the compressed gums has been chosen – by spraying on the adsorbent with subsequent mixing. Based on the studies, Syloid®244FP at a concentration of 1.0 % was chosen as the rational carrier.
Al Hagbani, T., Nazzal, S. (2018). Medicated Chewing Gums (MCGs): Composition, Production, and Mechanical Testing. AAPS PharmSciTech, 19 (7), 2908–2920. doi: http://doi.org/10.1208/s12249-018-1123-z
Aslani, A., Rostami, F. (2015). Medicated chewing gum, a novel drug delivery system. Journal of research in medical sciences, 20 (4), 403–411.
Shmidt, R., Tevs, G. (Eds.) (2012). Vkus i obonianie. Fiziologiia cheloveka. Vol. 1. Moscow: Mir, 304–311.
Ruban, O. A. et. al.; Pertseva, I. M. (Ed.) (2016). Dopomizhni rechovyny u vyrobnytstvi likiv. Kharkiv: Zoloti storinky, 720.
Chattopadhyay, S., Raychaudhuri, U., Chakraborty, R. (2011). Artificial sweeteners – a review. Journal of Food Science and Technology, 51 (4), 611–621. doi: http://doi.org/10.1007/s13197-011-0571-1
Council of Europe. European Pharmacopoeia (2016). Strasbourg: Council of Europe. Available at: https://www.coe.int/en/web/portal/-/the-9th-edition-european-pharmacopoeia-maintaining-high-quality-standards-in-a-dynamic-global-environment
The United States Pharmacopeia 39 – NationalFormulary 34 (2016). Washington: The United States Pharmacopeial Convention. Available at: https://www.worldcat.org/title/united-states-pharmacopeia-the-national-formulary/oclc/933365422
DSTU-N CODEXSTAN 192:2014 Kharchovi dobavky. Nomenklatura ta zahalni vymohy (CODEXSTAN 192-1995, Rev.9-2008, IDT), 246.
Maslii, Y., Ruban, O., Kolisnyk, T. (2019). Investigations with the aim of obtaining a mass for pressing medicated chewing gums “Lysodent C.” ScienceRise: Pharmaceutical Science, 3 (19), 11–16. doi: http://doi.org/10.15587/2519-4852.2019.172272
Rowe, R. C., Sheskey, P. J., Quinn, M. E. (Eds.) (2009). Sucralose. In Handbook ofPharmaceutical Excipients. London: Pharmaceutical Press and American Pharmacists Association, 701–703.
Maslii, Y. S., Ruban, O. A., Kovalevska, І. V. (2019). The choice of intense sweetener in the composition of medicated chewing gum under development. Farmatsevtychnyi Zhurnal, 5-6, 70–79. doi: http://doi.org/10.32352/0367-3057.5-6.18.05
Belmar, J., Ribé, M. (2013). Eye on Excipients. Health in Gum by Cafosa. Barcelona. As appeared in Tablets & Capsules. Available at: http://www.healthingum.com/pdf/Eye %20on %20excipients.pdf
Anurova, M. N., Bakhrushina, E. O., Pyatigorskaia, N. V., Yambikova, O. M. (2015). The principles of taste masking of oralgels with synthetic drugs. Pharmacy & Pharmacology, 4 (11), 15–20. doi: http://doi.org/10.19163/2307-9266-2015-3-4(11)-15-20
Anurova, M. N., Bakhrushina, E. O., Demina, N. B. (2015). Problemy korrektsii organolepticheskikh svoistv lekarstvennykh preparatov. Razrabotka i registratsiia lekarstvennykh sredstv, 4 (13), 64–73.
Derzhavna Farmakopeia Ukrainy. T. 1. (2015). Kharkiv: Derzhavne pidpryiemstvo «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv», 1128.
Sharma, D., Kumar, D., Singh, M. (2012). Taste masking technologies: a novel approach for the improvement of the organoleptic property of pharmaceutical active substance. International research journal of pharmacy, 3 (4), 108–116.
Rowe, R. C., Sheskey, P. J., Quinn, M. E. (Eds.) (2009). Colloidal Silicon Dioxide (Syloid). Handbook of Pharmaceutical Excipients. London: Pharmaceutical Press and American Pharmacists Association, 185–188.
Rowe, R. C., Sheskey, P. J., Quinn, M. E. (Eds.) (2009). Magnesium Aluminum Silicate (Neusilin). Handbook ofPharmaceutical Excipients. London: Pharmaceutical Press and American Pharmacists Association, 393–396.
Choudhari, Y., Reddy, U., Monsuur, F. (2016). Silikageli Syloid®FP – vspomogatelnye veschestva v proizvodstve tabletok. Afi i vspomogatelnye veschestva, 3 (264), 42–46.
Ingredienty dlia farmatsii. Neusilin® (2014). Farmatsevticheskaia otrasl, 5 (46), 25–27.
Swain, S., Patra, C. N., Bhanoji Rao, M. E. (Eds.) (2016). Pharmaceutical Drug Delivery Systems and Vehicles. India: Woodhead Publishing India Pvt. Ltd., 209–210.
Gumaste, S. G., Pawlak, S. A., Dalrymple, D. M., Nider, C. J., Trombetta, L. D., Serajuddin, A. T. M. (2013). Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates. Pharmaceutical Research, 30 (12), 3170–3185. doi: http://doi.org/10.1007/s11095-013-1114-4
Hentzschel, C. M., Alnaief, M., Smirnova, I., Sakmann, A., Leopold, C. S. (2011). Tableting properties of silica aerogel and other silicates. Drug Development and Industrial Pharmacy, 38 (4), 462–467. doi: http://doi.org/10.3109/03639045.2011.611806
Copyright (c) 2020 Yuliia Maslii, Оlena Ruban, Sergiy Kutsenko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.