UTERINE FIBROIDS IMPACT ON FERTILITY AND PREGNANCY OUTCOME

  • Olena Doroha Shupyk National Medical Academy of Postgraduate EducationState Scientific Institution "Scientific and Practical Center for Preventive and Clinical Medicine" of the State Administration of Affairs
  • Mykola Iarotskyi Academic Medical Center
  • Iryna Iarotska Shupyk National Medical Academy of Postgraduate Education
  • Liudmyla Semeniuk Ukrainian Scientific and Practical Center for Endocrine Surgery, Transportation Endocrine Organ and Tissues Ministry of Health of Ukraine http://orcid.org/0000-0002-7354-7061
  • Olga Nikitina State Scientific Institution "Scientific and Practical Center for Preventive and Clinical Medicine" of the State Administration of Affairs
Keywords: infertility, uterine fibroids, estrogen, progesterone, reproductive age, women

Abstract

The clinical confirmation of the relationship between uterine leiomyoma and female infertility is of interest to scholars.

The aim of our research was to study obstetric history and the level of sex hormones in women of reproductive age with leiomyoma.

Materials and methods. The main group consisted of 90 women of reproductive age with uterine leiomyoma, the control group - 45 healthy women. Gynaecological and obstetric history, hormone content in peripheral blood and pelvic vessels (estradiol, progesterone) were analysed. Statistical processing of clinical material was performed using Microsoft Excel, Statistica 7.0, and Statistica 8.0 for Windows.

Results. The frequency of infertility in the surveyed women with LM was 18.9 %. One in three patients in the main group (33.3 %) did not give birth, which was statistically different from the healthy women group. In this case, 25.6 % of women in the main group did not use any methods of contraception. It was found that 51.11 % of patients with LM had threatened miscarriage in their history, 37.5 % – complicated delivery. Pathological changes in the concentrations of estradiol and progesterone in the preferential blood and blood vessels of women with fibroids have been identified. We have found that the content of sex hormones in the local bloodstream has a reliable relationship with the location of the myomatous node.

Conclusion. The obtained results may indicate that leiomyoma contributes to the reduction of fertility. This is evidenced by the fact that women with LM are more likely to have the risk of miscarriage, complicated delivery and delivery by caesarean section, including complicated one. The findings have made a significant contribution to the further development of effective strategies for the prevention and treatment of infertility in women with fibrotic uterine lesions.

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Author Biographies

Olena Doroha, Shupyk National Medical Academy of Postgraduate EducationState Scientific Institution "Scientific and Practical Center for Preventive and Clinical Medicine" of the State Administration of Affairs

Department of Obstetrics, Gynecology And Perinatology

Ukrainian State Institute of Reproductology

Mykola Iarotskyi, Academic Medical Center

Medical director

Iryna Iarotska, Shupyk National Medical Academy of Postgraduate Education

Department of Obstetrics, Gynecology and Perinatology

Liudmyla Semeniuk, Ukrainian Scientific and Practical Center for Endocrine Surgery, Transportation Endocrine Organ and Tissues Ministry of Health of Ukraine

Department of Reproductive Medicine and Surgery

References

Carranza-Mamane, B., Havelock, J., Hemmings, R., Cheung, A., Sierra, S., Carranza-Mamane, B. et. al. (2015). The Management of Uterine Fibroids in Women With Otherwise Unexplained Infertility. Journal of Obstetrics and Gynaecology Canada, 37 (3), 277–285. doi: http://doi.org/10.1016/s1701-2163(15)30318-2

Salman, T., Davis, C. (2010). Uterine fibroids, management and effect on fertility. Current Opinion in Obstetrics and Gynecology, 22 (4), 295–303. doi: http://doi.org/10.1097/gco.0b013e32833d3606

Floss, K., Garcia-Rocha, G.-J., Kundu, S., von Kaisenberg, C., Hillemanns, P., Schippert, C. (2015). Fertility and Pregnancy Outcome after Myoma Enucleation by Minilaparotomy under Microsurgical Conditions in Pronounced Uterus Myomatosus. Geburtshilfe Und Frauenheilkunde, 75 (1), 56–63. doi: http://doi.org/10.1055/s-0034-1396163

Guo, X. C., Segars, J. H. (2012). The Impact and Management of Fibroids for Fertility. Obstetrics and Gynecology Clinics of North America, 39 (4), 521–533. doi: http://doi.org/10.1016/j.ogc.2012.09.005

Purohit, P., Vigneswaran, K. (2016). Fibroids and Infertility. Current Obstetrics and Gynecology Reports, 5 (2), 81–88. doi: http://doi.org/10.1007/s13669-016-0162-2

Katz, T. A., Yang, Q., Treviño, L. S., Walker, C. L., Al-Hendy, A. (2016). Endocrine-disrupting chemicals and uterine fibroids. Fertility and Sterility, 106 (4), 967–977. doi: http://doi.org/10.1016/j.fertnstert.2016.08.023

Dueholm, M., Lundorf, E., Hansen, E. S., Ledertoug, S., Olesen, F. (2001). Evaluation of the uterine cavity with magnetic resonance imaging, transvaginal sonography, hysterosonographic examination, and diagnostic hysteroscopy. Fertility and Sterility, 76 (2), 350–357. doi: http://doi.org/10.1016/s0015-0282(01)01900-8

Cook, H., Ezzati, M., Segars, J. H., McCarthy, D. (2010). The impact of uterine leiomyomas on reproductive outcomes. Minerva ginecologica, 62 (3), 225–236.

Pritts, E. A., Parker, W. H., Olive, D. L. (2009). Fibroids and infertility: an updated systematic review of the evidence. Fertility and Sterility, 91 (4), 1215–1223. doi: http://doi.org/10.1016/j.fertnstert.2008.01.051

Segars, J. H. (2014). Uterine Fibroid Research. Reproductive Sciences, 21 (9), 1065–1066. doi: http://doi.org/10.1177/1933719114546644

Segars, J. H., Akopians, A. L. (2013). The two health disparities of uterine fibroids. Fertility and Sterility, 99 (7), 1851–1852. doi: http://doi.org/10.1016/j.fertnstert.2013.03.002

Fornazari, V. A. V., Salazar, G. M. M., Vayego, S. A., Nunes, T. F., Goncalves, B., Szejnfeld, J. et. al. (2019). Impact of uterine contractility on quality of life of women undergoing uterine fibroid embolization. CVIR Endovascular, 2 (1). doi: http://doi.org/10.1186/s42155-019-0080-2

Shavell, V. I., Thakur, M., Sawant, A., Kruger, M. L., Jones, T. B., Singh, M. et. al. (2012). Adverse obstetric outcomes associated with sonographically identified large uterine fibroids. Fertility and Sterility, 97 (1), 107–110. doi: http://doi.org/10.1016/j.fertnstert.2011.10.009

Vlahos, N. F., Theodoridis, T. D., Partsinevelos, G. A. (2017). Myomas and Adenomyosis: Impact on Reproductive Outcome. BioMed Research International, 2017, 1–14. doi: http://doi.org/10.1155/2017/5926470

Lisiecki, M., Paszkowski, M., Woźniak, S. (2017). Fertility impairment associated with uterine fibroids – a review of literature. Menopausal Review, 16 (4), 137–140. doi: http://doi.org/10.5114/pm.2017.72759

Olive, D., Pritts, E. (2010). Fibroids and Reproduction. Seminars in Reproductive Medicine, 28 (3), 218–227. doi:10.1055/s-0030-1251478

Klatsky, P. C., Tran, N. D., Caughey, A. B., Fujimoto, V. Y. (2008). Fibroids and reproductive outcomes: a systematic literature review from conception to delivery. American Journal of Obstetrics and Gynecology, 198 (4), 357–366. doi: http://doi.org/10.1016/j.ajog.2007.12.039

Sunkara, S. K., Khairy, M., El-Toukhy, T., Khalaf, Y., Coomarasamy, A. (2009). The effect of intramural fibroids without uterine cavity involvement on the outcome of IVF treatment: a systematic review and meta-analysis. Human Reproduction, 25 (2), 418–429. doi: http://doi.org/10.1093/humrep/dep396

De Vivo, A., Mancuso, A., Giacobbe, A., Maggio Savasta, L., De Dominici, R., Dugo, N. et. al. (2011). Uterine myomas during pregnancy: a longitudinal sonographic study. Ultrasound in Obstetrics & Gynecology, 37 (3), 361–365. doi: http://doi.org/10.1002/uog.8826

Laughlin, S. K., Hartmann, K. E., Baird, D. D. (2011). Postpartum factors and natural fibroid regression. American Journal of Obstetrics and Gynecology, 204 (6), 496.e1–496.e6. doi: http://doi.org/10.1016/j.ajog.2011.02.018


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Published
2020-03-31
How to Cite
Doroha, O., Iarotskyi, M., Iarotska, I., Semeniuk, L., & Nikitina, O. (2020). UTERINE FIBROIDS IMPACT ON FERTILITY AND PREGNANCY OUTCOME. EUREKA: Health Sciences, (2), 52-58. https://doi.org/10.21303/2504-5679.2020.001205
Section
Medicine and Dentistry