Influence of cord blood serum and actovegin on the reproductive function of cows in the comparative aspect

Keywords: cows, cord blood serum, actovegin, correction of reproductive function

Abstract

The results of the study of the effect of cord blood serum and “Actovegin” (Takeda, Ukraine) on the reproductive function of cows in a comparative aspect are presented.

The aim of the study was to analyze the effect of cord blood serum and Actovegin on the reproductive function of uterine cows in a comparative aspect.

Materials and methods. The research was conducted during 2017-2020 in four dairy farms of Sumy region with tethered and untied maintenance. In 128 cows of different breeds and productivity, the timing of sexual cycling was studied and analyzed in comparison with the spontaneous sexual cycle with the use of cord blood serum and the drug "Actovegin" (Takeda, Ukraine).

Results. It was found that in cows with tethered content, the number of days from the introduction of 15 ml of cord blood serum to the manifestation of the excitation stage was significantly less compared to the spontaneous manifestation of sexual desire (5.63±0.36 and 14.38±2.1, respectively).

When cows with loose content were administered 10 ml of cord blood serum in combination with the drug "Actovegin", the number of days before the manifestation of sexual cycling was lower by 18.3 % compared with the rate of spontaneous sexual desire (4.31±0.38 and 18.25±1.89, respectively).

Conclusions. As a result of using 10 ml of cord blood serum in combination with the drug "Actovegin", in cows of different productivity and under different housing conditions, the number of days before the onset of the stage of arousal is significantly reduced compared to the spontaneous manifestation of sexual desire.

Cows of different productivity and with different housing conditions come to the sexual desire significantly faster with the use of 15 ml of cord blood serum compared to the spontaneous manifestation of sexual desire.

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Author Biographies

Irina Bondarenko, Sumy National Agrarian University

Department of Obstetrics and Surgery

Andrey Lazorenko, Sumy National Agrarian University

Department of Obstetrics and Surgery

Oksana Shkromada, Sumy National Agrarian University

Department of Obstetrics and Surgery

References

Yan, T., Venkat, P., Chopp, M., Zacharek, A., Ning, R., Cui, Y. et. al. (2015). Neurorestorative Therapy of Stroke in Type 2 Diabetes Mellitus Rats Treated With Human Umbilical Cord Blood Cells. Stroke, 46 (9), 2599–2606. doi: http://doi.org/10.1161/strokeaha.115.009870

Buchmayer, F., Pleiner, J., Elmlinger, M. W., Lauer, G., Nell, G., Sitte, H. H. (2011). Actovegin®: a biological drug for more than 5 decades. Wiener Medizinische Wochenschrift, 161 (3-4), 80–88. doi: http://doi.org/10.1007/s10354-011-0865-y

Panossian, A., Seo, E.-J., Efferth, T. (2019). Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells. Phytomedicine, 60, 152881. doi: http://doi.org/10.1016/j.phymed.2019.152881

Sun, J., Wang, J., Pefanis, E., Chao, J., Rothschild, G., Tachibana, I. et. al. (2015). Transcriptomics Identify CD9 as a Marker of Murine IL-10-Competent Regulatory B Cells. Cell Reports, 13 (6), 1110–1117. doi: http://doi.org/10.1016/j.celrep.2015.09.070

Zhang, J., Lv, S., Liu, X., Song, B., Shi, L. (2018). Umbilical cord mesenchymal stem cell treatment for crohn’s disease: a randomized controlled clinical trial. Gut Liver, 12, 73–78. doi: http://doi.org/10.5009/gnl17035

Wu, M., Zhang, R., Zou, Q., Chen, Y., Zhou, M., Li, X. et. al. (2018). Comparison of the Biological Characteristics of Mesenchymal Stem Cells Derived from the Human Placenta and Umbilical Cord. Scientific Reports, 8 (1). doi: http://doi.org/10.1038/s41598-018-23396-1

Van Pham, P., Dang, L. T.-T., Dinh, U. T., Truong, H. T.-T., Huynh, B. N., Van Le, D., Phan, N. K. (2013). In vitro evaluation of the effects of human umbilical cord extracts on human fibroblasts, keratinocytes, and melanocytes. In Vitro Cellular & Developmental Biology – Animal, 50 (4), 321–330. doi: http://doi.org/10.1007/s11626-013-9706-1

Brock, J., Golding, D., Smith, P. M., Nokes, L., Kwan, A., Lee, P. Y. F. (2018). Update on the Role of Actovegin in Musculoskeletal Medicine. Clinical Journal of Sport Medicine, 30 (1), 83–90. doi: http://doi.org/10.1097/jsm.0000000000000566

Lee, P., Kwan, A., Nokes, L. (2011). Actovegin® – Cutting-edge Sports Medicine or “Voodoo” Remedy? Current Sports Medicine Reports, 10 (4), 186–190. doi: http://doi.org/10.1249/jsr.0b013e318223cd8a

Riordan, N. H., Morales, I., Fernández, G., Allen, N., Fearnot, N. E., Leckrone, M. E. et. al. (2018). Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. Journal of Translational Medicine, 16 (1). doi: http://doi.org/10.1186/s12967-018-1433-7

Ren, H., Sang, Y., Zhang, F., Liu, Z., Qi, N., Chen, Y. (2016). Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy. Stem Cells International, 2016, 1–13. doi: http://doi.org/10.1155/2016/3516574

Mann, L., Snowise, S., Morales, Y., Prabhu, S., Tseng, S., Grill, R. et. al. (2016). Neurological Outcomes after Human Umbilical Cord Patch for In Utero Spina Bifida Repair in a Sheep Model. American Journal of Perinatology Reports, 6 (3), e309–e317. doi: http://doi.org/10.1055/s-0036-1592316

Kuchma, M. D., Kyryk, V. M., Svitina, H. M., Shablii, Y. M., Lukash, L. L., Lobyntseva, G. S., Shablii, V. A. (2015). Comparative Analysis of the Hematopoietic Progenitor Cells from Placenta, Cord Blood, and Fetal Liver, Based on Their Immunophenotype. BioMed Research International, 2015, 1–16. doi: http://doi.org/10.1155/2015/418752

Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., Caplan, A. I. (2019). Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regenerative Medicine, 4 (1). doi: http://doi.org/10.1038/s41536-019-0083-6

Nagaishi, K., Mizue, Y., Chikenji, T., Otani, M., Nakano, M., Saijo, Y. et. al. (2017). Umbilical cord extracts improve diabetic abnormalities in bone marrow-derived mesenchymal stem cells and increase their therapeutic effects on diabetic nephropathy. Scientific Reports, 7 (1). doi: http://doi.org/10.1038/s41598-017-08921-y

McLaughlin, C. A., West, T., Hollowell, R., Skergan, N. N., Baker, J., Donner, H. et. al. (2019). Expanded Access Protocol of Umbilical Cord Blood Infusion for Children with Neurological Conditions. STEM CELLS Translational Medicine, 8 (S1). doi: http://doi.org/10.1002/sctm.12583

Marston, W. A., Lantis, J. C., Wu, S. C., Nouvong, A., Lee, T. D., McCoy, N. D. et. al. (2019). An open‐label trial of cryopreserved human umbilical cord in the treatment of complex diabetic foot ulcers complicated by osteomyelitis. Wound Repair and Regeneration, 27 (6), 680–686. doi: http://doi.org/10.1111/wrr.12754

Kočí, Z., Výborný, K., Dubišová, J., Vacková, I., Jäger, A., Lunov, O. et. al. (2017). Extracellular Matrix Hydrogel Derived from Human Umbilical Cord as a Scaffold for Neural Tissue Repair and Its Comparison with Extracellular Matrix from Porcine Tissues. Tissue Engineering Part C: Methods, 23 (6), 333–345. doi: http://doi.org/10.1089/ten.tec.2017.0089

Ferdous, K. M. N. U., Hasan, M. S., Kabir, K. A., Zahid, M. K., Islam, M. K., Hasanuzzaman, M. (2018). Use of Umbilical Cord flap for Closure of Gastroschisis. Journal of Shaheed Suhrawardy Medical College, 10 (1), 47–50. doi: http://doi.org/10.3329/jssmc.v10i1.38904

Yamamoto, E., Niimi, K., Fujikake, K., Nishida, T., Murata, M., Mitsuma, A. et. al. (2016). High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review. Molecular and Clinical Oncology, 5 (5), 660–664. doi: http://doi.org/10.3892/mco.2016.1011

Doi, H., Kitajima, Y., Luo, L., Yan, C., Tateishi, S., Ono, Y. et. al. (2016). Potency of umbilical cord blood- and Wharton’s jelly-derived mesenchymal stem cells for scarless wound healing. Scientific Reports, 6 (1). doi: http://doi.org/10.1038/srep18844

Couto, P. S., Shatirishvili, G., Bersenev, A., Verter, F. (2019). First decade of clinical trials and published studies with mesenchymal stromal cells from umbilical cord tissue. Regenerative Medicine, 14 (4), 309–319. doi: http://doi.org/10.2217/rme-2018-0171


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Published
2021-05-25
How to Cite
Bondarenko, I., Lazorenko, A., & Shkromada, O. (2021). Influence of cord blood serum and actovegin on the reproductive function of cows in the comparative aspect. EUREKA: Health Sciences, (3), 101-109. https://doi.org/10.21303/2504-5679.2021.001834
Section
Veterinary Science and Veterinary Medicine