Peculiarities of intrauterine pathological processes in women of the postmenopauseal period

Keywords: postmenopause, pathological process of the endometrium, glandular-fibrous endometrial polyp, endometrial adenocarcinoma

Abstract

Aim of the research is studying the pecularities of the endometrium pathological processes in postmenopausal women on the basis of the hysteroscopy data evaluation, as well as conduction of histopathological and immunochemical studies.

Materials and methods. To study the pecularities of intrauterine pathological processes, 100 postmenopausal women were selected and studied. All women underwent hysteroscopy with separate diagnostic scraping of the uterine cavity. Also, 10 samples of glandular-fibrous endometrial polyps (GFEP) in women of reproductive age and 9 samples of such pathology in the postmenopausal period were studied by immunohistochemical method, using 6 primary specific monoclonal antibodies.

Results. The results showed that in 64 (64 %) postmenopausal women pathological changes of the endometrium were presented with GFEP, and in 2 patients (2 %) endometrial adenocarcinoma was found. It was also determined that the nuclei of epithelial and stromal cells of GFEP in postmenopausal women are characterized by lower expression of estrogen and progesterone receptors, compared with women with such formations in the reproductive age. In addition, it was found that in postmenopausal women the expression of the apoptosis inhibitor bcl-2 and aromatase P450 in the epithelial and stromal cells of GFEP was more expressed, and the expression of the Bах antigen, on the contrary, was significantly lower than in women of reproductive age.

Conclusions. Fundamental molecular-biological differences of GFEP in postmenopausal women compared with women of reproductive age were revealed. It was found that in postmenopausal women there is a significantly lower dependence of such polyps on the effects of estrogen and progesterone. In addition, the data indicate an increased risk of neoplastic transformation in such women.

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Author Biographies

Tetiana Polishchuk, Shupyk National Healthcare University of Ukraine

Department of Obstetrics, Gynecology and Perinatology

Ukrainian State Institute of Reproductology

Serhii Vdovichenko , Shupyk National Healthcare University of Ukraine

Department of Obstetrics, Gynecology and Perinatology

Ukrainian State Institute of Reproductology

Oleksandra Lubkovska, Shupyk National Healthcare University of Ukraine

Department of Obstetrics, Gynecology and Perinatology

Ukrainian State Institute of Reproductology

Dmytro Ledin, Shupyk National Healthcare University of Ukraine

Department of Obstetrics, Gynecology and Perinatology

Ukrainian State Institute of Reproductology

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Published
2021-05-25
How to Cite
Polishchuk, T., Vdovichenko , S., Lubkovska, O., & Ledin, D. (2021). Peculiarities of intrauterine pathological processes in women of the postmenopauseal period . EUREKA: Health Sciences, (3), 16-23. https://doi.org/10.21303/2504-5679.2021.001853
Section
Medicine and Dentistry