Female patients with androgenetic alopecia: immunohistochemical picture of scalp biopsies

Keywords: androgenetic alopecia, female patients, immunohistochemistry, inflammation, cytokines, growth factors, oxidative stress enzymes

Abstract

The aim of the research. To expand the knowledge about immunohistochemical changes in female patients with androgenetic alopecia (AGA) focusing on non-androgenic co-factors of pathogenesis of the disease, as this may serve as a basis for improving therapeutic regimens.

Materials and methods. Scalp biopsies of female patients with androgenetic alopecia were examined by immunohistochemical method. The study included two groups: the main group of 30 female patients aged 22 to 40 years, average age 32,13±5,03 years, and the control group that included 20 skin samples from women aged 25–40 years (average age 34,75±4,19 years) who underwent autopsies.

Results. It was found that AGA in women is characterized by a number of immunomorphological manifestations: the inflammatory infiltrate that consists of immunocompetent T-lymphocytes CD3+, CD4+ and CD8+, macrophages (CD68+); imbalance of growth polypeptides VEGF, TGF-β1, EGFR; accumulation of oxidative stress enzymes eNOS and iNOS; accumulation of pathological fraction of Collagen IV.

Conclusions. The data obtained by this study helps to improve the concept of morphogenesis of AGA, and also can become a base to improve the standards of treatment of the disease. The pathological triade “oxidative stress-microinflammation- fibrosis” should be considered as a possible treatment target, as well as the imbalance of growth peptides.

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Author Biography

Olena Salyenkova, V. N. Karazin Kharkiv National University

Department of Infectious Diseases and Clinical Immunology

School of Medicine

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Published
2021-09-30
How to Cite
Salyenkova, O. (2021). Female patients with androgenetic alopecia: immunohistochemical picture of scalp biopsies. EUREKA: Health Sciences, (5), 27-33. https://doi.org/10.21303/2504-5679.2021.002043
Section
Medicine and Dentistry