Immune response and phagocytosis of children with streptococcal tonsillitis and infected with the herpes virus type 6.

Keywords: streptococcal tonsillitis, herpes virus type 6, phagocytosis, cellular immunity, immunoglobulins


The aim of the work is to study the indicators of cellular and humoral immune response and FAN of patients with tonsillitis in children infected with HHV-6 type.

Materials and methods of research. In 72 children aged 3–15 years (mean age 8.42±1.44 years), patients with streptococcal tonsillitis of moderate severity, the levels of the main subpopulations of blood lymphocytes were determined using monoclonal antibodies by solid-phase enzyme-linked immunosorbent assay, phagocytic activity of neutrophils (FAN) using the nitrosine tetrazolium reduction test (HCT test) and serum IgA, IgM, IgG levels by radial immunodiffusion. The studies were carried out in the acute period and in the period of convalescence. Mathematical and statistical processing of the data obtained was carried out using Microsoft Excel 2003 and Statistica 6.0 programs. The significance of differences between the mean values was determined using the Student's test (t).

Results. Different mechanisms of formation of pathological process at streptococcal tonsillitis at children depending on the concomitant HHV-6 type infection are revealed. In patients with mixed infection in the acute period of tonsillitis determine the signs of deficiency of the cellular immune system with the maximum deviation of CD-lymphocytes (t=3.13 vs. t=2.16 in mono-infection), the tension in the humoral link of the immune response Ig deviation (t=1.63 against t=0.91 in mono-infection) on the background of phagocytosis violation in terms of FAN deviation (t=3.22 against t=2.01 in mono-infection). By the period of convalescence, the restoration of the imbalance of specific and non-specific protection factors does not occur. Increased IgG content in the acute period is one of the features of streptococcal tonsillitis in children on the background of HHV-6t infection.

Conclusions. Concomitant VGL-6 type infection in children with streptococcal tonsillitis affects the mechanisms of formation of the inflammatory process and the reactivity of patients, forming the preconditions for adverse outcomes of the disease. The obtained results can be the basis for early detection of herpes virus infection in patients with tonsillitis, will help to optimize the management of patients in different periods of the disease.


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Author Biographies

Viktoriia Olkhovska, Kharkiv Medical Academy of Postgraduate Education

Department of Pediatrics

Olga Olkhovska, Kharkiv National Medical University

Department of Pediatric Infectious Diseases

Zalina Yeloyeva, Kharkiv Medical Academy of Postgraduate Education

Department of Pediatrics


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How to Cite
Olkhovska, V., Olkhovska, O., & Yeloyeva, Z. (2021). Immune response and phagocytosis of children with streptococcal tonsillitis and infected with the herpes virus type 6 . EUREKA: Health Sciences, (5), 41-46.
Medicine and Dentistry