A cross-sectional study to assess proteinuria and lipoprotein (a) levels in chronic kidney disease

Keywords: proteinuria, lipoprotein, chronic kidney disease, glomerular filtration rate

Abstract

Chronic kidney disease (CKD) is a reduced glomerular filtration rate and/or increased urinary albumin excretion. The worldwide prevalence of chronic kidney disease (CKD) ranges from 8 to 16 %, and the prevalence of CKD is rising.

The aim: To study the association between CKD stages, proteinuria, and lipoprotein (a) levels among the study participants.

Materials and methods: This study was an institution-based observational case-control study involving CKD patients as study group and healthy volunteers as control one. Blood samples were tested for urea, serum creatinine, uric acid levels, triglycerides, total cholesterol, HDL cholesterol, VLDL cholesterol and serum lipoprotein. Statistical analysis was done with SPSS version 20.0.

Result: In our study, the most common age group affected among cases was 41 to 50 years (5th decade), and there was a male preponderance in CKD. CKD patients had a higher mean protein creatinine ratio than controls, and this difference was statistically significant. In addition, CKD patients had significantly higher total cholesterol, triglyceride levels and lower HDL cholesterol levels than controls. Also, they had significantly elevated serum lipoprotein (a) levels than controls.

Conclusion: Based on our study findings, we can conclude that because of the potential role of lipoprotein (a) in the development of cardiovascular disease, it is imperative to include an estimation of lipoprotein (a) levels in all CKD patients, especially in later stages to give a targeted therapy for dyslipidemia among CKD patients

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Author Biographies

Subalakshmi Radhakrishnan, Government Sivagangai Medical College & Hospital

Department of Biochemistry

Vijayapriya Indirajith, Dhanalakshmi Srinivasan Medical College & Hospital

Department of Biochemistry

Periyandi Chandran, Government Sivagangai Medical College & Hospital

Department of Biochemistry

Ganesan Subramanyam, Dhanalakshmi Srinivasan Medical College & Hospital

Department of Biochemistry

Menaha Ramu, Government Medical College & Hospital Karur

Department of Biochemistry

Suganya Kandhi, Sri Ramachandra Institute of Higher Education & Research

Department of Physiology

Pothanur Mayavan Sasikala, Government Medical College & Hospital Karur

Department of Biochemistry

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A cross-sectional study to assess proteinuria and lipoprotein (a) levels in chronic kidney disease

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Published
2022-07-31
How to Cite
Radhakrishnan, S., Indirajith, V., Chandran, P., Subramanyam, G., Ramu, M., Kandhi, S., & Sasikala, P. M. (2022). A cross-sectional study to assess proteinuria and lipoprotein (a) levels in chronic kidney disease. EUREKA: Health Sciences, (4), 32-38. https://doi.org/10.21303/2504-5679.2022.002567
Section
Medicine and Dentistry