Determination of the relationship of visphatin and homocysteine levels with indicators of glucose metabolism and lipid metabolism in peri- and postmenopause women with type 2 diabetes mellitus and osteoarthritis
Type 2 diabetes mellitus (T2DM), among other modern diseases, certainly occupies a leading position today. Moreover, the comorbid combination of T2DM and osteoarthritis (OA) is a common example of the development of complications, disability and mortality these days. As you know, T2DM develops against the background of obesity and overweight. A significant group of patients prone to these pathologies are peri- and postmenopausal women. Estrogen deficiency during this period worsens the course of these interdependent conditions. Therefore, searching for ways of early diagnosis of OA in women with T2DM is an urgent task of internal medicine.
Purpose. To determine the interdependencies of indicators of glucose metabolism and lipid metabolism with levels of visfatin (VF) and homocysteine (HC) in women with T2DM and OA in peri- and postmenopause.
Methods. For the study, 120 thematic women in peri- and postmenopause were selected and were divided into three groups: 1st (n=20) - women with a mono-course of T2DM; 2nd (n=20) – with a mono-course of OA; 3rd (n=64) – with the comorbid course of T2DM and OA. The control group (CG) consisted of 16 relatively healthy women of the appropriate age. Diagnoses of T2DM and OA were established in accordance with the current Orders of the Ministry of Health of Ukraine. Laboratory diagnostic methods were performed according to standard methods.
The results. According to the obtained results, the presence of interdependencies of all indicators of lipid metabolism and glucose-insulin metabolism was reliably determined, which indicated direct correlations (mostly of moderate strength) with the levels of HC and VF in the blood of the examinees, most pronounced in the comorbid combination of T2DM and OA in peri- and postmenopause.
Conclusions. In work, an analysis of the correlations of indicators of glucose metabolism and lipid metabolism with disturbances in the metabolism of VF and HC in women with T2DM and OA in pre- and postmenopause was carried out, and their interdependent relationships were determined. The highest levels of VF and HC were recorded in the group of women with comorbid pathology of T2DM and OA.
Dzyuba, O. M., Pazynych, L. M., Sitenko, O. R., Kryvenko, Ye. M. (2017). The actual questions of global burden of diseases in Ukraine. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, 2, 8–13. doi: https://doi.org/10.11603/1681-2786.2017.2.8101
WHO. The top 10 causes of death (2020). Available at: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death Last assessed: 11.11.2020
Zhou, B., Lu, Y., Hajifathalian, K., Bentham, J., Di Cesare, M., Danaei, G. et al. (2016). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants. The Lancet, 387 (10027), 1513–1530. doi: https://doi.org/10.1016/s0140-6736(16)00618-8
Lin, X., Xu, Y., Pan, X., Xu, J., Ding, Y., Sun, X. et al. (2020). Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Scientific Reports, 10 (1). doi: https://doi.org/10.1038/s41598-020-71908-9
Ogurtsova, K., da Rocha Fernandes, J. D., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H. et al. (2017). IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Research and Clinical Practice, 128, 40–50. doi: https://doi.org/10.1016/j.diabres.2017.03.024
Simon, C., Narayanan, N., Binu, J., Rajmohan, P. (2017). Prevalence and Risk Factors of Type 2 Diabetes Mellitus among Adults in a Rural Area of Thrissur, Kerala (Type 2 Diabetes among Adults in Rural Thrissur, Kerala). Journal of Medical Science and Clinical Research, 5. (9), 28303–28310. doi: https://doi.org/10.18535/jmscr/v5i9.156
IDF. International Diabetes Federation. IDF Diabetes Atlas (2015). Belgium.
IDF Western Pacific. International diabetes federation (2020). Available at: https://idf.org/our-network/regions-members/western-pacific/welcome.html
Onyango, E. M., Onyango, B. M. (2018). The Rise of Noncommunicable Diseases in Kenya: An Examination of the Time Trends and Contribution of the Changes in Diet and Physical Inactivity. Journal of Epidemiology and Global Health, 8 (1-2). doi: https://doi.org/10.2991/j.jegh.2017.11.004
Seiglie, J. A., Marcus, M.-E., Ebert, C., Prodromidis, N., Geldsetzer, P., Theilmann, M. et al. (2020). Diabetes Prevalence and Its Relationship With Education, Wealth, and BMI in 29 Low- and Middle-Income Countries. Diabetes Care, 43 (4), 767–775. doi: https://doi.org/10.2337/dc19-1782
Cowie, C. C., Casagrande, S. S., Geiss, L. S. (2018). Prevalence and Incidence of Type 2 Diabetes and Prediabetes. Diabetes in America. National Institute of Diabetes and Digestive and Kidney Diseases (US), Bethesda (MD).
Global Burden of Disease database (2017). Institute for health metrics and evaluation. Seattle, Washington.
Alva, P., Bhandary, A., Bhandary, P., Hegde, P., Souza, N. D., Kumari, S. (2021). Correlation of Body Mass Index with Lipid Profile and Estradiol in Postmenopausal Women with Type 2 Diabetes Mellitus. International Journal of Current Research and Review, 13 (1), 107–110. doi: https://doi.org/10.31782/ijcrr.2021.13107
Porta, S., Otero-Losada, M., Kölliker Frers, R. A., Cosentino, V., Kerzberg, E., Capani, F. (2021). Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis. Frontiers in Immunology, 11. doi: https://doi.org/10.3389/fimmu.2020.590749
Zheng, Y., Ley, S. H., Hu, F. B. (2017). Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature Reviews Endocrinology, 14 (2), 88–98. doi: https://doi.org/10.1038/nrendo.2017.151
Lascar, N., Brown, J., Pattison, H., Barnett, A. H., Bailey, C. J., Bellary, S. (2018). Type 2 diabetes in adolescents and young adults. The Lancet Diabetes & Endocrinology, 6 (1), 69–80. doi: https://doi.org/10.1016/s2213-8587(17)30186-9
Asiimwe, D., Mauti, G. O., Kiconco, R. (2020). Prevalence and Risk Factors Associated with Type 2 Diabetes in Elderly Patients Aged 45-80 Years at Kanungu District. Journal of Diabetes Research, 2020, 1–5. doi: https://doi.org/10.1155/2020/5152146
Mobasseri, M., Shirmohammadi, M., Amiri, T., Vahed, N., Hosseini Fard, H., Ghojazadeh, M. (2020). Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis. Health Promotion Perspectives, 10 (2), 98–115. doi: https://doi.org/10.34172/hpp.2020.18
Hevko, U. P., Dikova, I. G., Maksiv, Kh. Ya., Dzyha, S. V., Bakalets, O. V., Behosh, N. B. (2021). Type 2 diabetes mellitus and its comorbidity. Bulletin of Medical and Biological Research, 4, 132–136. doi: https://doi.org/10.11603/bmbr.2706-6290.2020.4.11827
Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020: Estimates of Diabetes and Its Burden in the United States. Centers for Disease Control and Prevention, U.S (2020). Dept of Health and Human Services. Available at: https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf Last accessed: 22.12.2020
Song, P., Hwang, J. S., Park, H. C., Kim, K. K., Son, H.-J., Kim, Y.-J., Lee, K. M. (2021). Therapeutic Applications of Type 2 Diabetes Mellitus Drug Metformin in Patients with Osteoarthritis. Pharmaceuticals, 14 (2), 152. doi: https://doi.org/10.3390/ph14020152
Konnur, R. G. (2021). Osteoarthritis and Menopause. International Journal of Orthopedic Nursing, 7 (1), 1–8.
Mahajan, A., Patni, R. (2018). Menopause and Osteoarthritis: Any Association ? Journal of Mid-Life Health, 9 (4), 171–172. doi: https://doi.org/10.4103/jmh.jmh_157_18
Wu, J. H. et al. (2021). Prevalence and risk factors of osteoarthritis in patients with type 2 diabetes in Beijing, China from 2015 to 2017. Journal of Peking University. Health Sciences, 53 (3), 518–522. doi: 10.19723/j.issn.1671-167x.2021.03.013
Gürsoy, G., Akçayöz, S., Acar, Y., Demirba, B. (2011). Visfatin in hyperlipidemic female patients. International Journal of Medical Advances and Discovery, 2 (5), 1–6.
Koebnick, C., Black, M. H., Wu, J., Shu, Y.-H., MacKay, A. W., Watanabe, R. M. et al. (2018). A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile. British Journal of Nutrition, 120 (11), 1230–1239. doi: https://doi.org/10.1017/s0007114518002726
Bitto, A., Arcoraci, V., Alibrandi, A., D’Anna, R., Corrado, F., Atteritano, M., Minutoli, L., Altavilla, D., Squadrito, F. (2016). Visfatin correlates with hot flashes in postmenopausal women with metabolic syndrome: effects of genistein. Endocrine, 55 (3), 899–906. doi: https://doi.org/10.1007/s12020-016-0968-8
Hug, C., Lodish, H. F. (2005). Visfatin: A New Adipokine. Science, 307 (5708), 366–367. doi: https://doi.org/10.1126/science.1106933
Kim, J.-H., Kim, S.-H., Im, J.-A., Lee, D.-C. (2010). The relationship between visfatin and metabolic syndrome in postmenopausal women. Maturitas, 67 (1), 67–71. doi: https://doi.org/10.1016/j.maturitas.2010.05.002
Chhezom, K., Arslan, M. I., Hoque, Md. M., Biswas, S. K. (2017). Biomarkers of cardiovascular and metabolic diseases in otherwise healthy overweight subjects in Bangladesh. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 11, S381–S384. doi: https://doi.org/10.1016/j.dsx.2017.03.021
Farkhondeh, T., Llorens, S., Pourbagher-Shahri, A. M., Ashrafizadeh, M., Talebi, M., Shakibaei, M., Samarghandian, S. (2020). An Overview of the Role of Adipokines in Cardiometabolic Diseases. Molecules, 25 (21), 5218. doi: https://doi.org/10.3390/molecules25215218
Bawah, A. T., Seini, M. M., Abaka-Yawason, A., Alidu, H., Nanga, S. (2019). Leptin, resistin and visfatin as useful predictors of gestational diabetes mellitus. Lipids in Health and Disease, 18 (1). doi: https://doi.org/10.1186/s12944-019-1169-2
Ezzati-Mobaser, S., Malekpour-Dehkordi, Z., Nourbakhsh, M., Tavakoli-Yaraki, M., Ahmadpour, F., Golpour, P., Nourbakhsh, M. (2020). The up-regulation of markers of adipose tissue fibrosis by visfatin in pre-adipocytes as well as obese children and adolescents. Cytokine, 134, 155193. doi: https://doi.org/10.1016/j.cyto.2020.155193
Wnuk, A., Stangret, A., Wątroba, M., Płatek, A. E., Skoda, M., Cendrowski, K. et al. (2020). Can adipokine visfatin be a novel marker of pregnancy‐related disorders in women with obesity? Obesity Reviews, 21 (7). doi: https://doi.org/10.1111/obr.13022
Parker, R., Kim, S.-J., Gao, B. (2017). Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations. Nature Reviews Gastroenterology & Hepatology, 15 (1), 50–59. doi: https://doi.org/10.1038/nrgastro.2017.116
Guoli, C., Kuichen, Z., Liqiu, L., Sheng, L. I. (2016). Relevance of serum visfatin, lipoprotein-a and homocysteine in diabetic nephropathy. Chinese Journal of Biochemical Pharmaceutics, 36 (6), 182–184.
Filippatos, T., Randeva, H., Derdemezis, C., Elisaf, M., Mikhailidis, D. (2010). Visfatin/PBEF and Atherosclerosis-Related Diseases. Current Vascular Pharmacology, 8 (1), 12–28. doi: https://doi.org/10.2174/157016110790226679
Uslu, S., Kebapçi, N., Kara, M., Bal, C. (2012). Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 4 (1), 113–120. doi: https://doi.org/10.3892/etm.2012.557
Franco-Trepat, E., Guillán-Fresco, M., Alonso-Pérez, A., Jorge-Mora, A., Francisco, V., Gualillo, O., Gómez, R. (2019). Visfatin Connection: Present and Future in Osteoarthritis and Osteoporosis. Journal of Clinical Medicine, 8 (8), 1178. doi: https://doi.org/10.3390/jcm8081178
Tsai, C.-H., Liu, S.-C., Chung, W.-H., Wang, S.-W., Wu, M.-H., Tang, C.-H. (2020). Visfatin Increases VEGF-Dependent Angiogenesis of Endothelial Progenitor Cells during Osteoarthritis Progression. Cells, 9 (5), 1315. doi: https://doi.org/10.3390/cells9051315
Moretti, R., Caruso, P. (2019). The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice. International Journal of Molecular Sciences, 20 (1), 231. doi: https://doi.org/10.3390/ijms20010231
Chrysant, S. G., Chrysant, G. S. (2018). The current status of homocysteine as a risk factor for cardiovascular disease: a mini review. Expert Review of Cardiovascular Therapy, 16 (8), 559–565. doi: https://doi.org/10.1080/14779072.2018.1497974
Djuric, D., Jakovljevic, V., Zivkovic, V., Srejovic, I. (2018). Homocysteine and homocysteine-related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems. Canadian Journal of Physiology and Pharmacology, 96 (10), 991–1003. doi: https://doi.org/10.1139/cjpp-2018-0112
Zaric, B. L., Obradovic, M., Bajic, V., Haidara, M. A., Jovanovic, M., Isenovic, E. R. (2019). Homocysteine and Hyperhomocysteinaemia. Current Medicinal Chemistry, 26 (16), 2948–2961. doi: https://doi.org/10.2174/0929867325666180313105949
Smith, A. D., Refsum, H. (2021). Homocysteine – from disease biomarker to disease prevention. Journal of Internal Medicine, 290 (4), 826–854. doi: https://doi.org/10.1111/joim.13279
Azzini, E., Ruggeri, S., Polito, A. (2020). Homocysteine: Its Possible Emerging Role in At-Risk Population Groups. International Journal of Molecular Sciences, 21 (4), 1421. doi: https://doi.org/10.3390/ijms21041421
Saito, M., Marumo, K. (2018). The Effects of Homocysteine on the Skeleton. Current Osteoporosis Reports, 16 (5), 554–560. doi: https://doi.org/10.1007/s11914-018-0469-1
Hindy, G., Åkesson, K. E., Melander, O., Aragam, K. G., Haas, M. E., Nilsson, P. M. et al. (2019). Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes: A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank. Arthritis & Rheumatology, 71 (6), 925–934. doi: https://doi.org/10.1002/art.40812
Tsiklauri, L., Werner, J., Frommer, K., Engel, R., Rehart, S., Wenisch, S. et al. (2018). Visfatin in bone metabolism of osteoporosis and osteoarthritis patients. Poster Presentations. doi: https://doi.org/10.1136/annrheumdis-2018-ewrr2018.114
Çıkım, G., Veranyurt, Ü. (2021). Evaluation of homocysteine and vitamin d levels in osteoarthritis patients. NWSA Academic Journals, 16 (2), 68–73. doi: https://doi.org/10.12739/nwsa.2021.16.2.1b0109
👁 28 ⬇ 30
Copyright (c) 2023 Larysa Zhuravlyova, Valentyna Cherpita
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.