COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF CHRONOTHERAPY AND TRADITIONAL METHOD OF ALOPECIA AREATA TREATMENT
Alopecia areata – is the one of widespread baldness forms, difficultly subjected to treatment. The method of chronotherapy that gains an essential circulation in Ukraine and throughout the world may play the important role in its solution.
Aim: to study the clinical effectiveness of chronotherapy for alopecia areata treatment.
Materials and methods. For attaining the set aim 108 persons with the diagnosis alopecia areata were examined and treated. Patients were divided in two groups. The main group included 45 persons – treated using the method of chronotherapy. The control group consisted of 67 persons, who received the traditional treatment of alopecia areata. The series of clinical, biochemical and immunological studies, directed on the assessment of the treatment effectiveness, were realized.
Results. The treatment of patients with alopecia areata by the method of chronotherapy is statistically reliably more effective than the traditional treatment of this pathology and provides the renewal of hair growth in 53,3 % of patients that is accompanied by normalization of alexin, sulfhydryl groups content, acid phosphatase activity, serine, asparagine acid, valine, threonine, alanine, cystine, leucine, isoleucine concentrations. The offered chronotherapy method has the expressed anabolic effect on patients’ organism. The menstrual cycle is normalized, pre-menstrual syndrome symptoms and aldodysmenorrhea disappear, patients’ working ability and state of health improve.
Conclusions. The obtained data deepen knowledge about the pathogenesis of alopecia areata at the biochemical and immunological levels and favor the rise of the effectiveness of diagnostics and treatment of this pathology. At the study the high chronotherapy effectiveness at treating alopecia areata was revealed and the possibility of its use for the effective treatment of a series of other pathologies was proved.
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