COMPARISON OF QUALITY OF LIFE OF PATIENTS WITH LOCAL DISTRIBUTED BREAST CANCER FORMS AFTER CHEMOTHERAPY IN REGIONAL AND SYSTEM REGIMES

  • Yuriy Dumanskiy Donetsk medical university
  • Oleksandr Bondar Odessa National Medical University University clinic of Odessa medical university
  • Oleksandr Tkachenko Odesa state medical university
  • Evhenii Stoliachuk University clinic of Odessa National Medical University
  • Vasilii Ermakov University clinic of Odessa National Medical University
Keywords: locally advanced breast cancer, complex treatment, intra-arterial polychemotherapy, systemic polychemotherapy, quality of life

Abstract

For several decades, breast cancer (BC) undoubtedly ranks first in the structure of oncopathology and is the most common cause of the loss of working capacity of the female population in most countries. Considering the increasing quality of care for patients with breast cancer, there is the need for standardization and implementation of methods to assess not only quantitative but also qualitative component of a comprehensive opinion on the results of therapy. Therefore, an important indicator to be taken into account is the quality of life (QL) of a patient.

Definition of QL of patients with inoperable forms of locally advanced breast cancer before and after neoadjuvant courses of systemic polychemotherapy (SPCT) and selective intra-arterial polychemotherapy in combination with systemic (SIAPCT).

154 patients with LA BC T4A-DN0-3M0, who received comprehensive treatment on the basis of the Donetsk regional antitumor center and the University clinic of the Odessa National Medical University during the period from 2000 to 2017, who received SPCT or SIAPCT as a neoadjuvant course, were included in the study.

According to the quality of life during the treatment period, wavelike dynamics with a clear advantage of selective intra-arterial polychemotherapy over the system was observed. According to the quality of health between groups, the marginal statistically significant difference in favour of regional PCTs was formed.

In a detailed study of each of the options found stable symptomatic scale dependent components of the integral index of quality of life on the severity and duration of intoxication syndrome. On the basis of the results obtained, the statistical advantage of the RMRM remains with the regional PCT.

The QL study is a reliable, informative and economical method for assessing the health status of the patient, both at the group and at the individual level. In cancer studies, the evaluation of QL is an important criterion for assessing the effectiveness of treatment and has a prognostic value.

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Author Biographies

Yuriy Dumanskiy, Donetsk medical university

Department of the oncology and radiology

Oleksandr Bondar, Odessa National Medical University University clinic of Odessa medical university

Department of surgery No. 4 with oncology

Heard of the mammology department

Oleksandr Tkachenko, Odesa state medical university

Department of surgery No. 4 with oncology

Evhenii Stoliachuk, University clinic of Odessa National Medical University

Department of the surgical

Vasilii Ermakov, University clinic of Odessa National Medical University

Department of the surgical

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Published
2018-05-31
How to Cite
Dumanskiy, Y., Bondar, O., Tkachenko, O., Stoliachuk, E., & Ermakov, V. (2018). COMPARISON OF QUALITY OF LIFE OF PATIENTS WITH LOCAL DISTRIBUTED BREAST CANCER FORMS AFTER CHEMOTHERAPY IN REGIONAL AND SYSTEM REGIMES. EUREKA: Health Sciences, (3), 12-20. https://doi.org/10.21303/2504-5679.2018.00635
Section
Medicine and Dentistry