FEATURES OF CONNECTIVE TISSUE METABOLISM AND MICROELEMENTS IN BLOOD SERUM OF PREGNANT WOMEN WITH CERVICAL INSUFFICIENCY

  • Sadrudin Magomedov State Institution "The Institute of Traumatology and Orthopedics" of National Academy of Medical Sciences of Ukraine, Ukraine
  • Iryna Zhabchenko State Institution "The Institute of Traumatology and Orthopedics" of National Academy of Medical Sciences of Ukraine, Ukraine
  • Viktor Oleshko O. O. Bogomolets National Medical University,, Ukraine
  • Larysa Polishchuk State Institution "The Institute of Traumatology and Orthopedics" of National Academy of Medical Sciences of Ukraine, Ukraine
  • Nellia Korniets State Institution "Lugansk State Medical University", Ukraine
  • Olga Krynicka State Institution "The Institute of Traumatology and Orthopedics" of National Academy of Medical Sciences of Ukraine, Ukraine
Keywords: pregnancy, undifferentiated connective tissue dysplasia, markers of synthesis and resorption, microelements

Abstract

The preterm deliveries are the leading cause of the perinatal morbidity and represent important mortality indicators. Functional cervical insufficiency, which is a phenotypic manifestation of undifferentiated connective tissue dysplasia, plays the main role in the development of pregnancy complications in primigravidas (women pregnant for the first time) and primiparas (women giving birth for the first time).

Aim of the research: to study the indicators of connective tissue metabolism and basic microelements in order to determine the role of undifferentiated connective tissue dysplasia in the pathogenesis of functional cervical insufficiency during pregnancy.

Methods. The 101 pregnant women (the main group) at the 22–32 week gestation period which were diagnosed with “Functional cervical insufficiency” were examined, as well as 34 pregnant women with the physiological obstructive function of the cervix (the control group). Utilizing immunoenzyme analysis we measured in blood serum the concentration of Total P1NP the amino-terminal propeptide of procollagen type I a marker of synthesis, and β-CrossLaps resorptions marker of the connective tissue. Utilizing the automatic analyzer of electrolytes and a set of reagents for their determination we estimated the content of microelements Na+, K+, Mg2+, Ca2+ and total Ca and P.

Results. The functional cervical insufficiency in pregnant women was indicated by cervical shortening up to 22.88±1.02 mm, and the majority of women (76.2 %) had phenotypical manifestations of undifferentiated connective tissue dysplasia. We found a significant increase in the concentration of marker of synthesis Total P1NP, whereas the concentration of resorption marker β-CrossLaps remains normal, and strong reverse correlation (r=–0.7362) between the index of cervix length and concentration of marker of connective tissue synthesis Total P1NP. We detected a significant increase in the concentration of total and ionized calcium, total phosphorus, deficiency of ionized magnesium, potassium and sodium that lead to changes in the structure of connective tissue and reduction of cervical obstructive function.

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Author Biographies

Sadrudin Magomedov, State Institution "The Institute of Traumatology and Orthopedics" of National Academy of Medical Sciences of Ukraine

Laboratory of Biochemical and Clinical Analysis

Iryna Zhabchenko, State Institution "The Institute of Traumatology and Orthopedics" of National Academy of Medical Sciences of Ukraine

Department of Pathology of Pregnancy and Delivery

Viktor Oleshko, O. O. Bogomolets National Medical University,

Department No. 3 of Obstetrics and Gynecology

Larysa Polishchuk, State Institution "The Institute of Traumatology and Orthopedics" of National Academy of Medical Sciences of Ukraine

Laboratory of Biochemical and Clinical Analysis

Nellia Korniets, State Institution "Lugansk State Medical University"

Department of Obstetrics and Gynecology

Olga Krynicka, State Institution "The Institute of Traumatology and Orthopedics" of National Academy of Medical Sciences of Ukraine

Laboratory of Biochemical and Clinical Analysis

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Published
2018-11-30
How to Cite
Magomedov, S., Zhabchenko, I., Oleshko, V., Polishchuk, L., Korniets, N., & Krynicka, O. (2018). FEATURES OF CONNECTIVE TISSUE METABOLISM AND MICROELEMENTS IN BLOOD SERUM OF PREGNANT WOMEN WITH CERVICAL INSUFFICIENCY. EUREKA: Health Sciences, (6), 30-36. https://doi.org/10.21303/2504-5679.2018.00784
Section
Medicine and Dentistry