Bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress

  • Liliia Kalachniuk National University of Life and Environmental Sciences of Ukraine
  • Petro Fedyshyn National University of Life and Environmental Sciences of Ukraine
  • Oleh Smirnov Institute of Animal Biology NAAS
  • Viktoriia Prys-Kadenko National University of Life and Environmental Sciences of Ukraine
  • Roman Palonko National University of Life and Environmental Sciences of Ukraine
  • Oleksii Arnauta National University of Life and Environmental Sciences of Ukraine
Keywords: alcohol-induced oxidative stress, amino acids, biochemical parameters, bio protectors, rats

Abstract

The studies, which may reveal some elements of regulation between the metabolic processes of proteins (at the level of translation and changes in the amino acid spectrum) as well as catabolism and anabolism of carbohydrates under conditions of pathological deviations of the functioning of the animal organism, are promising, and the search for protective substances of a different nature is necessary.

The aim is to study and analyze a bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress.

During the experimental period, changes in the body weight of rats confirm the depressant effect of alcohol on the dynamics of weight gain of animals during their growth and development, and the positive protective effect of betaine and additives (protein+minerals).

The increased activity of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase in the blood serum of rats in experimental groups of animals with the absence of protectors’ substances in the diet indicates a deviation in the functional capacity of the liver. The determined indices of the content of creatinine and urea were increased significantly that points out on possible pathological deviation of the kidney. Under alcohol substances, changes of such biochemical indexes value as lactate dehydrogenase, superoxide dismutase, and catalase, and the content of malonic dialdehyde indicate oxidative stress. In the case of bio protectors’ presence, values of biochemical parameters become to ones in the animals of control groups.

It was observed, that betaine has a higher potential for the correction of the above pathological abnormalities than protein-containing additives with minerals in the form of chelate, but the last is perspective for further study and their use as a raw material for the development of more complex bio protectors

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Author Biographies

Liliia Kalachniuk, National University of Life and Environmental Sciences of Ukraine

Professor

Department of Biochemistry and Physiology of Animals named after Academician M. F. Gulyi

Petro Fedyshyn, National University of Life and Environmental Sciences of Ukraine

Department of Biochemistry and Physiology of Animals named after Academician M. F. Gulyi

Oleh Smirnov, Institute of Animal Biology NAAS

Postgraduate Student

Laboratory of Molecular Biology and Clinical Biochemistry

Viktoriia Prys-Kadenko, National University of Life and Environmental Sciences of Ukraine

Senior Laboratory Assistant

Department of Biochemistry and Physiology of Animals named after Academician M. F. Gulyi

Roman Palonko, National University of Life and Environmental Sciences of Ukraine

Postgraduate Student

Department of Biochemistry and Physiology of Animals named after Academician M. F. Gulyi

Oleksii Arnauta, National University of Life and Environmental Sciences of Ukraine

Senior Research Fellow

Department of Biochemistry and Physiology of Animals named after Academician M. F. Gulyi

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Published
2021-07-30
How to Cite
Kalachniuk, L., Fedyshyn, P., Smirnov, O., Prys-Kadenko, V., Palonko, R., & Arnauta, O. (2021). Bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress. EUREKA: Life Sciences, (4), 50-57. https://doi.org/10.21303/2504-5695.2021.001985
Section
Immunology and Microbiology