ANALYSIS OF PECULIARITIES OF EPILEPTIC SEIZURES AND STRUCTURAL DAMAGES OF BRAIN IN PATIENTS WITH ISCHEMIC STROKE

Keywords: epilepsy, ischemic stroke, acute cerebrovascular disease, diagnosis, structural damages, computed tomography, magnetic resonance imaging

Abstract

The aim of the research: epilepsy on the background of ischemic stroke.

Studied problem: improve of diagnosis of epilepsy on the background of ischemic stroke by establishing the clinical features of epileptic seizures and by detection of brain structural damages

The main scientific results: a cross-sectional randomized cohort comparative study with retrospective and prospective stages was performed in 60 patients (men and women) with ischemic stroke aged 65 [57.0; 74.0] years, in 30 of which epileptic seizures were detected. The predominance of generalized single (66.7±38.5 %) variants was found in the structure of epileptic seizures in patients with acute cerebrovascular pathology. A higher frequency of generalized variants of seizures in patients over 60 years of age (maximum at 61–70 years, at descending – 71–80 years, over 80 years) has been revealed. The descending distribution of localization frequency of brain lesions (detected with MRI, CT) in patients with epileptic seizures after ischemic stroke is as follows: dilation of the subarachnoid space (93.3±24.1 %), dilation of the brain ventricles (83.3±34.0 %), subcortical ganglia (76.7±37.0 %), right hemisphere or temporal lobe (60.0±37.9 %), subcortex (56.7±37.3 %), frontal lobe (50.0±35.4 %), left hemisphere or diffuse-atrophic changes in the cortical region (43.3±32.6 %), temporal lobe (20.0±17.9 %), occipital lobe (16.7±15.2 %).

The area of practical use of the research results: clinical medicine, especially neurology.

Innovative technological product: methodology of diagnosis of epilepsy on the background of ischemic stroke.

Scope of the innovative technological product: the evaluation of seizures and brain’s structural damages in patients with ischemic stroke with the development of epileptic seizures may be a means of improving the diagnosis of epilepsy on the background of cerebrovascular disease.

Downloads

Download data is not yet available.

Author Biographies

Marianna Mushehian, Kharkiv Medical Academy of Postgraduate Education

Department of neurology and child neurology

Tetyana Litovchenko, Kharkiv Medical Academy of Postgraduate Education

Department of neurology and child neurology

References

Scheffer, I. E., Berkovic, S., Capovilla, G., Connolly, M. B., French, J., Guilhoto, L. et. al. (2017). ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 58 (4), 512–521. doi: http://doi.org/10.1111/epi.13709

Trinka, E., Cock, H., Hesdorffer, D., Rossetti, A. O., Scheffer, I. E., Shinnar, S. et. al. (2015). A definition and classification of status epilepticus – Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 56 (10), 1515–1523. doi: http://doi.org/10.1111/epi.13121

Xu, M. Y. (2018). Poststroke seizure: optimising its management. Stroke and Vascular Neurology, 4 (1), 48–56. doi: http://doi.org/10.1136/svn-2018-000175

Miyaji, Y., Kawabata, Y., Joki, H., Seki, S., Mori, K., Kamide, T. et. al. (2017). Late Seizures after Stroke in Clinical Practice: The Prevalence of Non-convulsive Seizures. Internal Medicine, 56 (6), 627–630. doi: http://doi.org/10.2169/internalmedicine.56.7162

Assadeck, H., Toudou-Daouda, M., Mamadou, Z., Moussa-Konate, M., Hassane-Djibo, F., Douma-Maiga, D. (2019). Clinical and Etiological Characteristics of Epilepsy in the Elderly: A Hospital-Based Study from a Tertiary Care Referral Center of Niamey, Niger. Journal of Neurosciences in Rural Practice, 10 (4), 571–575. doi: http://doi.org/10.1055/s-0039-1700308

Birenbaum, D., Bancroft, L. W., Felsberg, G. J. (2011). Imaging in Acute Stroke. Western Journal of Emergency Medicine, 12 (1), 67–76.

Guerrero, W. R., Golubczyk, D., Walczak, P. (2019). Thrombus Imaging in Acute Stroke. Stroke, 50 (8), 1948–1949. doi: http://doi.org/10.1161/strokeaha.119.025866

Kubiak-Balcerewicz, K., Fiszer, U., Nagańska, E., Siemianowski, C., Sobieszek, A., Witak-Grzybowska, A., Kosińska-Szot, A. (2017). Differentiating Stroke and Seizure in Acute Setting – Perfusion Computed Tomography? Journal of Stroke and Cerebrovascular Diseases, 26 (6), 1321–1327. doi: http://doi.org/10.1016/j.jstrokecerebrovasdis.2017.02.002

López Ruiz, R., Quintas, S., Largo, P., de Toledo, M., Carreras, M. T., Gago-Veiga, A. et. al. (2019). Usefulness of multiparametric computerised tomography findings in the differential diagnosis of stroke mimics of epileptic origin: A preliminary study. Neurología, 34 (2), 73–79. doi: http://doi.org/10.1016/j.nrleng.2018.11.001

Koome, M., Churilov, L., Chen, Z., Chen, Z., Naylor, J., Thevathasan, A. et. al. (2016). Computed tomography perfusion as a diagnostic tool for seizures after ischemic stroke. Neuroradiology, 58 (6), 577–584. doi: http://doi.org/10.1007/s00234-016-1670-5

Austein, F., Huhndorf, M., Meyne, J., Laufs, H., Jansen, O., Lindner, T. (2017). Advanced CT for diagnosis of seizure-related stroke mimics. European Radiology, 28 (5), 1791–1800. doi: http://doi.org/10.1007/s00330-017-5174-4

Katramados, A. M., Hacein-Bey, L., Varelas, P. N. (2018). What to Look for on Post-stroke Neuroimaging. Neuroimaging Clinics of North America, 28 (4), 649–662. doi: http://doi.org/10.1016/j.nic.2018.06.007

Chen, G., Lei, D., Ren, J., Zuo, P., Suo, X., Wang, D. J. J. et. al. (2016). Patterns of postictal cerebral perfusion in idiopathic generalized epilepsy: a multi-delay multi-parametric arterial spin labelling perfusion MRI study. Scientific Reports, 6 (1). doi: http://doi.org/10.1038/srep28867

Gaxiola-Valdez, I., Singh, S., Perera, T., Sandy, S., Li, E., Federico, P. (2017). Seizure onset zone localization using postictal hypoperfusion detected by arterial spin labelling MRI. Brain, 140 (11), 2895–2911. doi: http://doi.org/10.1093/brain/awx241

Liang, J., Gao, P., Lin, Y., Song, L., Qin, H., Sui, B. (2018). Susceptibility-weighted imaging in post-treatment evaluation in the early stage in patients with acute ischemic stroke. Journal of International Medical Research, 47 (1), 196–205. doi: http://doi.org/10.1177/0300060518799019

Leigh, R., Krakauer, J. W. (2014). MRI-guided selection of patients for treatment of acute ischemic stroke. Current Opinion in Neurology, 27 (4), 425–433. doi: http://doi.org/10.1097/wco.0000000000000110

Cartagena, A. M., Young, G. B., Lee, D. H., Mirsattari, S. M. (2014). Reversible and irreversible cranial MRI findings associated with status epilepticus. Epilepsy & Behavior, 33, 24–30. doi: http://doi.org/10.1016/j.yebeh.2014.02.003

Ohe, Y., Hayashi, T., Deguchi, I., Fukuoka, T., Horiuchi, Y., Maruyama, H. et. al. (2014). MRI abnormality of the pulvinar in patients with status epilepticus. Journal of Neuroradiology, 41 (4), 220–226. doi: http://doi.org/10.1016/j.neurad.2013.09.003

Conrad, J., Pawlowski, M., Dogan, M., Kovac, S., Ritter, M. A., Evers, S. (2013). Seizures after cerebrovascular events: Risk factors and clinical features. Seizure, 22 (4), 275–282. doi: http://doi.org/10.1016/j.seizure.2013.01.014

Brigo, F., Schneider, M., Wagenpfeil, G., Unger, M. M., Holzhoffer, C., Walter, S. et. al. (2020). Early poststroke seizures following thrombolysis and/or thrombectomy for acute stroke: Clinical and stroke characteristics. Epilepsy & Behavior, 104, 106353. doi: http://doi.org/10.1016/j.yebeh.2019.05.048

Ghika, J., Bogousslavsky, J., van Melle, G., Regit, F. (1995). Hyperkinetic Motor Behaviors Contralateral to Hemiplegia in Acute Stroke. European Neurology, 35 (1), 27–32. doi: http://doi.org/10.1159/000117085

Kim, B. S., Sila, C. (2015). Seizures in Ischemic Stroke. In. Koubeissi MZ, ed. Seizures in cerebrovascular disorders. New York: Springer Science+Business Media, 17–29. doi: http://doi.org/10.1007/978-1-4939-2559-9_2


👁 131
⬇ 71
Published
2020-10-31
How to Cite
Mushehian, M., & Litovchenko, T. (2020). ANALYSIS OF PECULIARITIES OF EPILEPTIC SEIZURES AND STRUCTURAL DAMAGES OF BRAIN IN PATIENTS WITH ISCHEMIC STROKE. ScienceRise, (5), 46-53. https://doi.org/10.21303/2313-8416.2020.001454
Section
Innovative technologies in healthcare