@article{Alieva_2021, title={THE STUDY OF SOCIAL-MEDICAL AND GENETIC RISKS OF REPRODUCTIVE LOSSES }, url={https://journal.eu-jr.eu/sciencerise/article/view/1668}, DOI={10.21303/2313-8416.2021.001668}, abstractNote={<p><strong>Object of research:</strong> homozygous and heterozygous disorders of genes encoding the enzymes of the folate cycle, methylenetetrahydrofolate reductase (<em>MTHFR</em>) and methionine-synthase-reductase (<em>MTRR</em>).</p> <p><strong>Solved problem:</strong> an in-depth study of genetically determined risk factor’s influence for reproductive losses associated with homozygous and heterozygous disorders of folate cycle genes.</p> <p><strong>Main scientific results:</strong> in-depth study of genetically determined reproductive losses as a systemic phenomenon was held. The structural characteristics of reproductive losses in population and significant predominance of pathology in the pedigrees of those examined with a burdened obstetric history of reproductive losses were determined. Also, a significant increase in the chances of reproductive loss in patients with heterozygous and homozygous inheritance of <em>MTHFR</em> and <em>MTRR</em> genes was determined. A correlation effect on the degree of genomic polymorphism of the <em>MTHFR</em> and <em>MTRR</em> gene was noted.</p> <p><strong>Area of practical use of research results: </strong>medical-genetic institutions.</p> <p><strong>Innovative technological product:</strong> determination of genetically risk factors for growth of reproductive losses of the population associated with homozygous and heterozygous disorders of genes encoding the enzymes of the folate cycle (<em>MTHFR C677T</em> and <em>MTRR A66G</em>). Timely adjustment of folic acid levels allows to prevent birth defects and reduce reproductive losses</p> <p><strong>Scope of application of the innovative technological product:</strong> clinical medical-genetic practice using the ability to determine the polymorphism of genes <em>MTHFR </em>and<em> MTRR</em>, which makes it possible to timely adjust the level of folic acid and prevent the reproductive losses.</p&gt;}, number={1}, journal={ScienceRise}, author={Alieva, Tarana Dzhafar Kyzy}, year={2021}, month={Feb.}, pages={41-49} }