LEFT VENTRICULAR HYPERTROPHY AND LEFT ATRIAL DILATATION AS MARKERS OF MALIGNANT ARRHYTHMIAS DEVELOPMENT
One of the pressing problems of modern cardiology is the study of the etiological and risk factors for sudden cardiac death (SCD). Arrhythmias, which in most cases correlate with signs of myocardial hypertrophy, are important for its occurrence. The most common cause of left ventricular hypertrophy (LVH) is hypertension. However, an equally important trigger mechanism for malignant arrhythmias is coronary heart disease (CHD). It is known that LVH is considered as an independent risk factor for cardiovascular complications.
Methods. The study design included an assessment of the effect of cardiac remodelling, the degree of LVH, and the degree of dilatation of left atrium (LA) on the development of malignant disorders of rhythm and conduction of the heart (DRCH). 78 patients with II degree of hypertension were examined. Patients were divided into two groups depending on the presence of CHD. In each group, there were malignant rhythm and conduction disorders. The control group consisted of 20 healthy people.
Results and discussion. The stages of LVH were equally represented in both groups, but the concentric LVH, the initial degree of LVH, and the dilatation of LA predominated. In patients with malignant DRCH, a moderate degree of LVH predominated. Significantly, more likely malignant DRCH occurred in the second group and presented with high-grade ventricular extrasystoles, prolonged QT interval, and sinus node weakness syndrome.
Novytska, A. V., Sukhovatenko, V. I. (2015). Likuvannia ishemichnoi khvoroby sertsia: mozhlyvosti ta perevahy metabolichnoi tsytoprotektsii ta anhioprotektsii. Liky Ukrainy, 9-10 (195-196), 10–14.
Denesiuk, O. V., Denesiuk, V. I. (2015). Dynamika stupeniv remodeliuvannia i systolo-diastolichnoi dysfunktsii livoho shlunochka pry nestabilnii stenokardii pid vplyvom optymalnoho tryvaloho likuvannia. Visnyk problem biolohii ta medytsyny, 2 (1 (118)), 121–126.
Korkushko, O. V., Lyshnevska, V. Yu., Bodretska, L. A. (2007). Morfofunktsionalni zminy livoho peredserdia u khvorykh na ishemichnu khvorobu sertsia z chastoiu peredserdnoiu ekstrasystoliieiu v pokhylomu vitsi. Klinichna medytsyna, 1, 26–30.
Golovach, I. Iu. (2013) Gipertrofiia levogo zheludochka i arterialnaia gipertenziia: novye patogeneticheskie i terapevticheskie koncepcii. Novosti mediciny i farmacii, 9, 3–5.
Bart, B. Ia., Vartanian, E. A., Dergunova, E. N., Skakova, T. I. (2004). Strukturno-funkcionalnye izmeneniia levogo predserdiia pri arterialnoi gipertonii i ikh dinamika v processe medikamentoznoi terapii. Rossiiskii kardiologicheskii zhurnal, 2 (46), 20–25.
Denesiuk, V., Denesiuk, O. (2015). The use of improved working clinical and prognostic classification of life-thereatening arrhythmias and heart blocks in different cardiovascular diseases (reported and own findings). The Pharma Innovation Journal, 4 (10), 61–63.
Denesiuk, V. I., Sarafyniuk, O. B., Muzyka, N. O., Denesiuk, O. V., Afanasiuk, O. I. (2013). Pat. No. 86395 UA. Sposib diahnostyky stupeniv hipertrofii livoho shlunochka u khvorykh z sertsevo-sudynnymy zakhvoriuvanniamy. MPK: A61B 5/00. No. u 2013 08823; declareted: 15.07.2013; published: 25.12.13. Bul. No. 24.
Treshkur, T. V. (2002) Kliniko-elektrokardiograficheskaia kharakteristika ishemicheskikh zheludochkovykh aritmіi. Vesnik aritmologii, 30, 31–38.
Barnett, O. Yu. (2011) Arterialna hipertenziia ta hipertrofiia livoho shlunochka: neobkhidnist kontroliu za indeksom masy miokarda livoho shlunochka. AML, XVII, 17–20.
De Vecchis, R., Ariano, C., Di Biase, G., Noutsias, M. (2018). Malignant Ventricular Arrhythmias Resulting From Drug-Induced QTc Prolongation: A Retrospective Study. Journal of Clinical Medicine Research, 10 (7), 593–600. doi: http://doi.org/10.14740/jocmr3470w
Copyright (c) 2019 Yuliia Shushkovska, Oksana Afanasiuk
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.