OMENTIN METABOLISM AND PATHOPHYSIOLOGICAL RELATIONSHIP BETWEEN ITS LEVEL AND THE SEVERITY OF LESIONS IN THE INTIMA-MEDIA THICKNESS OF THE CAROTID ARTERIES IN TYPE 2 DIABETES MELLITUS IN COMBINATION WITH OBESITY

Keywords: omentin-1, obesity, excess body weight, type 2 diabetes mellitus, intima-media thickness

Abstract

The relationship of visceral obesity and excess body weight (EBW) with the development of cardiovascular diseases, type 2 diabetes mellitus (DM) and effect on quality and duration of life determine the relevance of studying this problem.

The aim: to assess omentin-1 metabolism and pathophysiological relationship between its level and the severity of lesions in the intima-media thickness (IMT) of the carotid arteries in type 2 DM in combination with EBW and obesity.

Materials and methods. We examined 98 people with DM, the first group consisted of 64 people with EBW and obesity, second group consisted of 34 people with normal body weight, control group – 28 healthy individuals. The concentration of omentin-1 was investigated by ELISA by solid-phase enzyme-linked immunosorbent assay in vitro. Ultrasound of the carotid arteries was performed in the lying position of the patient on the device MyLab50X with a linear sensor of 7 MHz with a slight deviation of the patient's head in the opposite direction.

Results. Evaluation of the correlation matrix showed the presence of a positive rather strong negative connection between IMT, especially the right carotid artery and the level of omentin-1 in the blood (Rs = –0.55; p = 0.002). The largest number of individuals with omentin-1 levels from 5–10 ng / ml had significant disorders of the vascular wall (IMT from 1.0 to 1.2 mm).

Conclusion. Obtained data indicate a statistically significant associative relationship between the dynamics of the predictor of cardiovascular risk – IMT with the degree of impaired expression of omentin-1.

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Author Biographies

Roman Kulynych, Zaporizhzhia State Medical University

Departments of Internal Diseases No. 3

Olena Soloviuk, State Institution "Zaporozhye Medical Academy of Postgraduate Education Ministry of Health of Ukraine"

Department of Therapy, Clinical Pharmacology and Endocrinology

Oleksandr Soloviuk, Zaporizhzhia State Medical University

Department of Internal Diseases 1 and simulation medicine

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Published
2020-10-29
How to Cite
Kulynych, R., Soloviuk, O., & Soloviuk, O. (2020). OMENTIN METABOLISM AND PATHOPHYSIOLOGICAL RELATIONSHIP BETWEEN ITS LEVEL AND THE SEVERITY OF LESIONS IN THE INTIMA-MEDIA THICKNESS OF THE CAROTID ARTERIES IN TYPE 2 DIABETES MELLITUS IN COMBINATION WITH OBESITY. Technology Transfer: Innovative Solutions in Medicine, 24-27. https://doi.org/10.21303/2585-663.2020.001490
Section
Medicine and Dentistry