TOXICOLOGICAL ASSESSMENT OF COMBINED FUNGICIDES PROPOSED FOR APPLICATION ON CEREAL SPIKED CROPS IN UKRAINE

  • Mykola Kondratiuk Bogomolets National Medical University 13 T. Shevchenko blvd., Kyiv, Ukraine, 01601
  • Anna Blagaia Bogomolets National Medical University 13 T. Shevchenko blvd., Kyiv, Ukraine, 01601
Keywords: combined fungicides, acute oral, dermal, inhalation toxicity, irritation potential, and sensitization

Abstract

Toxicological assessment of combined fungicides proposed for application on cereal spiked crops in Ukraine was performed according approved State Sanitary Norms and Rules. Statistics, bibliographical methods were used in the study. The classes of hazard were established after evaluation of toxicometry parameters, which included assessment of acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, irritation potential to eyes (mucous membranes) and skin, and sensitizing properties. Integral hazard class of the studied formulations was established. Formulations No.1, 2, 3, 5 and 7 can be pertained to integral hazard class 2 by acute inhalation toxicity as limiting criterion of hazard (formulation No.1 also has additional point of concern – its irritation of the skin and eyes). Formulation No.4, 6 and 8 were classified as integral hazard class 3 by the same limiting criterion of hazard, but the danger of formulation No.4 possibility to cause sensitization and irritation of the eyes was taken into account. Recommendations for the studied combined fungicides application in agricultural sector of Ukraine were given. Maximum daily time of contact with formulations for workers engaged in its application on cereal spiked crops was suggested. 4 hours per day were approved for formulations No.1,2,3,5 and 7, and 6 hours per day for No. 6 and 8, respectively

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Author Biographies

Mykola Kondratiuk, Bogomolets National Medical University 13 T. Shevchenko blvd., Kyiv, Ukraine, 01601
Department of hygiene and ecology No.1
Anna Blagaia, Bogomolets National Medical University 13 T. Shevchenko blvd., Kyiv, Ukraine, 01601
Department of hygiene and ecology No.1

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Published
2017-10-26
How to Cite
Kondratiuk, M., & Blagaia, A. (2017). TOXICOLOGICAL ASSESSMENT OF COMBINED FUNGICIDES PROPOSED FOR APPLICATION ON CEREAL SPIKED CROPS IN UKRAINE. Technology Transfer: Innovative Solutions in Medicine, 41-43. https://doi.org/10.21303/2585-663.2017.00442
Section
Pharmacology, Toxicology and Pharmaceutical Science