MICROBIOLOGICAL STUDIES OF ANTI-HISTAMINE SUPPOSITORIES "LORAVIT" FOR CHILDREN
Among the current problems of medicine and pharmacy, attracting the attention of researchers around the world, allergic diseases are on an important place; for example, bronchial asthma, allergic rhinitis, atopic dermatitis, and others. These pathologies affect their abundance not only among adults, but also among children . According to statistics, almost every child had allergic reactions to drugs, food, clothing, hygiene products, etc. at least once . In this regard, we have developed a new anti-allergic drug for children in the form of suppositories under the conditional name "Loravit".
The purpose of this work was to conduct microbiological research of new anti-allergic drug "Loravit" for children in the rectal dosage form.
During researches, the correlation of the growth properties of nutrients was analyzed and the microbiological purity of the drug "Loravit" was studied. A thioglyсol semi-liquid substratum, Saburo’s substratum, solid nutrient substrata: nutrient agar, Saburo’s substratum, Chistovich's substratum, nutrient agar based on blood agar, Endo’s substratum, and also test microorganisms - Staphylococcus aureus ATCC 6538, Esherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 9027, Bacillus subtilis ATCC 6633, Candida albicans ATCC 885/653 were used for carrying out these studies.
In the study of microbiological purity, the method of direct seeding on liquid nutrient substrata and the method of deep sowing were applied.
As a result of the conducted studies it was established that a new medicinal product for children in the form of suppositories for the treatment of allergic diseases meets the requirements of the State Pharmacopoeia of Ukraine and European Pharmacopeia for the indicator "Microbiological purity". The norms of microbiological purity of suppositories "Loravit" are also established. The test results were included in the draft quality control methods for the developed drug.
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