SUBSTANTIATION OF THE MEDICINE WITH DRY EXTRACT OF HOP CONES IN THE FORM OF HARD GELATINE CAPSULES FOR TREATMENT OF GASTROINTESTINAL DISEASES DEVELOPMENT EXPEDIENCY
The aim of the work was to justify the feasibility of developing a new drug with a dry extract of hop cones in the form of hard gelatin capsules for the treatment of gastrointestinal diseases.
Methods. In order to study the range of medicines based on hop cones on the pharmaceutical market of Ukraine, a marketing analysis of registered drugs has been conducted. The marketing analysis was carried out using the information of retrieval system "Drugs" by "Morion" LLC and the State Register of Medicines of Ukraine, which allows quickly tracking changes in the structure of offers. To systematize the main characteristics of the studied drug of hop cones, to assess its strengths and weaknesses, opportunities and threats, a modern marketing method – SWOT-analysis has been used. In the process of research, methods of system analysis, monitoring, logical generalization, grouping of marketing research, etc. were used.
Results. The methodology of research has been developed and justified. The main types of pharmacological activity of extracts from hop raw materials have been reviewed. A comprehensive study of the drug from hop cones using the SWOT-analysis method has allowed analyzing its strengths and weaknesses, which can contribute to or hamper the progress and consolidation of this drug in a certain market segment. It was revealed that the strengths of the drug are much greater than the weaknesses, and this speaks in favor of its competitiveness in the pharmaceutical market of Ukraine.The discussion of the results. The medical and marketing expediency of developing a new medicinal preparation with a dry extract of hop cones in the form of capsules for use in gastroenterology have been proved
ICH Topic Q8 (R2). Part I. Pharmaceutical Development (EMEA/СHМР/167068/2004 Note for Guidance on Pharmaceutical Development).
Ulbricht, C., Basch, E., Basch, S., Chao, W., Conquer, J., Costa, D. et. al. (2012). Hops (Humulus lupulus): An Evidence-Based Systematic Review by the Natural Standard Research Collaboration. Alternative and Complementary Therapies, 18 (2), 98–108. doi: 10.1089/act.2012.18204
Zanoli, P., Zavatti, M. (2008). Pharmacognostic and pharmacological profile of Humulus lupulus L. Journal of Ethnopharmacology, 116 (3), 383–396. doi: 10.1016/j.jep.2008.01.011
Bi, W. P., Man, H. B., Man, M. Q. (2014). Efficacy and safety of herbal medicines in treating gastric ulcer: A review. World Journal of Gastroenterology, 20 (45), 17020–17028. doi: 10.3748/wjg.v20.i45.17020.
Koetter, U., Biendl, M. (2010). Hops (Humulus lupulus): A Review of its Historic and Medicinal Uses. HerbalGram, 87 (5), 44–57.
Kurasawa, T., Chikaraishi, Y., Naito, A., Toyoda, Y., Notsu, Y. (2005). Effect of humulus lupulus on Gastric Secretion in a Rat Pylorus-Ligated Model. Biological & Pharmaceutical Bulletin, 28 (2), 353–357. doi: 10.1248/bpb.28.353
Vanhoecke, B., Derycke, L., Van Marck, V., Depypere, H., De Keukeleire, D., Bracke, M. (2005). Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer. International Journal of Cancer, 117 (6), 889–895. doi: 10.1002/ijc.21249
Schubert, M. L. (2010). Gastric secretion. Current Opinion in Gastroenterology, 26 (6), 598–603. doi: 10.1097/mog.0b013e32833f2010
Schubert, M. L., Peura, D. A. (2008). Control of Gastric Acid Secretion in Health and Disease. Gastroenterology, 134 (7), 1842–1860. doi: 10.1053/j.gastro.2008.05.021
Bland, J. S., Minich, D., Lerman, R., Darland, G., Lamb, J., Tripp, M., Grayson, N. (2015). Isohumulones from hops (Humulus lupulus) and their potential role in medical nutrition therapy. PharmaNutrition, 21 (2), 46–52. doi: 10.1016/j.phanu.2015.03.001
Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., Winterhoff, H. (2006). Sedating effects of Humulus lupulus L. extracts. Phytomedicine, 13 (8), 535–541. doi: 10.1016/j.phymed.2006.05.010
Van Cleemput, M., Cattoor, K., De Bosscher, K., Haegeman, G., De Keukeleire, D., Heyerick, A. (2009). Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds. Journal of Natural Products, 72 (6), 1220–1230. doi: 10.1021/np800740m
Copyright (c) 2017 Sergiy Kutsenko, Nataliya Gerbina
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.