SOME MARKERS OF SYSTEMIC INFLAMMATORY RESPONSE AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH NEUROLOGIC MANIFESTATIONS OF LUMBAR OSTEOCHONDROSIS

  • Shadid Fadi Bukovinian State Medical University 2 Theatralna sq., Chernivtsi, Ukraine, 58002
  • Igor Krychun Bukovinian State Medical University 2 Theatralna sq., Chernivtsi, Ukraine, 58002
Keywords: Radiculopathy, lumbalgia, lumbar ischialgia, endothelium-dependent vasodilation, fibronectin, sFlt-1, endothelial dysfunction, systemic inflammatory response, Celermayer’s test, TNF-α

Abstract

It has been established in numerous experimental and clinical studies that disc protrusion leads to a number of immunobiochemical processes and the inflammatory response of the body. It leads to a question: Aren’t the processes of herniation accompanied with endothelial dysfunction which can develop in connection with the chronic inflammatory process? The following research goal is set to address these issues: to study blood plasma for the content of some chronic inflammation markers and endothelial damage such as fibronectin, tumor necrosis factor (TNF-α) and soluble fms-like tyrosine kinase-1 (sFlt-1) in combination with the investigation of the functional state of the endothelium using Celermayer’s test in males under the age of 45 without signs of obesity and somatic or vascular pathology with various neurologic manifestations of lumbar osteochondrosis.

85 male patients have been examined for neurologic manifestations of spinal osteochondrosis at the age from 19 to 45. The examined patients included 45 individuals with radiculopathy verified by neuroimaging and 40 individuals with reflex manifestations of lumbar osteochondrosis.

It has been shown that the examined patients of young age with exacerbation of discogenic radiculopathy accompanied with a prolonged pain syndrome experience an increase of fibronectin and tumor necrosis factor-alpha in plasma against the background of a decrease in the concentration of soluble fms-like tyrosine kinase-1 that are markers of inflammation and endothelial damage.

The obtained data imply that patients with neurologic manifestations of osteochondrosis need active preventive measures of cardiovascular diseases with the mandatory inclusion of endothelial-tropic therapy

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Author Biographies

Shadid Fadi, Bukovinian State Medical University 2 Theatralna sq., Chernivtsi, Ukraine, 58002
Department of Nervous Diseases, Psychiatry and Medical Psychology
Igor Krychun, Bukovinian State Medical University 2 Theatralna sq., Chernivtsi, Ukraine, 58002
Department of Nervous Diseases, Psychiatry and Medical Psychology

References

Dagenais, S., Caro, J., Haldeman, S. (2008). A systematic review of low back pain cost of illness studies in the United States and internationally. The Spine Journal, 8 (1), 8–20. doi: 10.1016/j.spinee.2007.10.005

Risbud, M. V., Shapiro, I. M. (2013). Role of cytokines in intervertebral disc degeneration: pain and disc content. Nature Reviews Rheumatology, 10 (1), 44–56. doi: 10.1038/nrrheum.2013.160

Giatromanolaki, A., Sivridis, E., Athanassou, N., Zois, E., Thorpe, P. E., Brekken, R. A. et. al. (2001). The angiogenic pathway «vascular endothelial growth factor/flk-1(KDR)-receptor» in rheumatoid arthritis and osteoarthritis. The Journal of Pathology, 194 (1), 101–108. doi: 10.1002/path.842

Takada, T., Nishida, K., Maeno, K., Kakutani, K., Yurube, T., Doita, M., Kurosaka, M. (2012). Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats. Arthritis & Rheumatism, 64 (8), 2601–2610. doi: 10.1002/art.34456

Shibuya, M. (2006). Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis. Angiogenesis, 9 (4), 225–230. doi: 10.1007/s10456-006-9055-8

Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D. et. al. (1992). Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. The Lancet, 340 (8828), 1111–1115. doi: 10.1016/0140-6736(92)93147-f

Ikeda, M., Hosoda, Y., Hirose, S., Okada, Y., Ikeda, E. (2000). Expression of vascular endothelial growth factor isoforms and their receptors Flt-1, KDR, and neuropilin-1 in synovial tissues of rheumatoid arthritis. The Journal of Pathology, 191 (4), 426–433. doi: 10.1002/1096-9896(2000)9999:9999<::aid-path649>3.0.co;2-e

Podichetty, V. K. (2007). The aging spine: the role of inflammatory mediators in intervertebral disc degeneration. Cellular and Molecular Biology, 53 (5), 4–18.

Pancov, R., Yamada, K. M. (2002). Fibronectin at a glance. Journal of Cell Science, 115 (20), 3861–3863. doi: 10.1242/jcs.00059

Krychun, I. I., Shadid Fadi Haza (2017). Pokazateli sostoyanie endoteliya u bolnykh molodogo vozrasta s obostreniem khronicheskoy diskogennoy lyumbalgii [Indicators of Endothelium Condition of Young Patients with Exacerbation of Chronic Discogenic Lumbalgia]. Eurasian Scientific Association, 1 (1 (23)), 87–89.


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Published
2017-10-26
How to Cite
Fadi, S., & Krychun, I. (2017). SOME MARKERS OF SYSTEMIC INFLAMMATORY RESPONSE AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH NEUROLOGIC MANIFESTATIONS OF LUMBAR OSTEOCHONDROSIS. Technology Transfer: Innovative Solutions in Medicine, 35-37. https://doi.org/10.21303/2585-663.2017.00461
Section
Medicine and Dentistry