THE ASPECTS OF DEVELOPMENT AND STANDARDIZATION OF CHILDREN’S SUPPOSITORIES WITH EXTRACT OF LICORICE ROOT
The aim of this work was the development of technology of rectal suppositories of immunomodulatory action for children and their standardization.
To obtain suppositories, a licorice root extract, chamomile and tea tree essential oils were used. Given that the introduction of ingredients in a dissolved form is preferable, we studied the possibility of using emulsion suppository bases. To evaluate the compositions, the homogeneity and colloidal stability of the suppositories obtained were studied. Estimation of homogeneity, melting temperature, decay time, average mass was carried out according to the State Pharmacopoeia. To confirm the authenticity of the active ingredients, a chromatography method was used. The quantitative determination of glycyrrhizin acid was carried out by spectrophotometric method.
Suppositories were prepared by the pouring method. The licorice root extract was added to the suppository when dissolved in the hydrophilic phase of the base. Essential oils of chamomile and tea tree were introduced when a solid fat of type A dissolved in a melt, at a temperature of (42.0±2.0) ºC. Optimum indices for the criteria of “homogeneity” and “colloidal stability” were noted for the samples of the composition: purified water, polysorbate-80, lecithin, solid fat type A. To prove the authenticity of the licorice root extract in suppositories, the chloroform-methanol-water system was optimal (26:14:3). Identification of essential oils on a gas chromatograph showed that on the chromatogram the peaks and retention times of the solution under study coincide with the peaks and retention times of the reference solutions. The conducted studies of quantitative determination of glycyrrhizin acid have shown that its content in one suppository is not less than 0.035 g in terms of glycyram.
Romantsov, M. G., Ershov, F. I., Kovalenko, A. L. (2010). Protivovirusnyie preparatyi dlya lecheniya ORVI i grippa u detey (klinicheskiy obzor) [Antiviral drugs for treatment of acute respiratory viral infections and influenza in children (clinical review)]. Fundamentalnyie issledovaniya [Basic research], 9, 76–87.
Yarnykh, T. H., Melnyk, H. M., Rukhmakova, O. A. (2013). Analiz farmrynku protyvirusnykh dytiachykh preparative [An analysis of the pharmaceutical market of antiviral children's products]. Proceedings from Functional foods – dietary supplements – as an effective means of diverse prevention of diseases. Kharkiv: ESEN, 283–284.
Yarnykh, T. H., Melnyk, H. M. (2013). Rozrobka skladu dytiachykh supozytoriiv na osnovi pryrodnoi roslynnoi syrovyny [Development of children's suppositories based on natural raw materials]. Farmatsevtychnyi chasopys [Pharmaceutical magazine], 1 (25), 98–101.
Yarnyih, T. G., Tolochko, E. V., Chushenko, V. N. (2010). Izuchenie assortimenta suppozitornyih osnov (obzor) [The study of the assortment of suppository bases (review)]. Himiko-farmatsevticheskiy zhurnal [Chemical-Pharmaceutical Journal], 44 (10), 21–26.
Tykhonov, O. I., Yarnykh, T. H. (Eds.) (2015). Vymohy do vyhotovlennia nesterylnykh likarskykh zasobiv v umovakh aptek [Requirements for the manufacture of non-sterile medicines in pharmacies]. Kyiv: Ministerstvo okhorony zdorovia Ukrainy.
Derzhavna farmakopeia Ukrainy [State Pharmacopoeia of Ukraine] (2001). Derzhavne pidpryiemstvo «Naukovo-ekspertnyi farmakopeinyi tsentr». Kharkiv: RIREH, 531.
Georgievskiy, V. P. (Ed.) (2011). Analiticheskaya himiya v sozdanii, standartizatsii i kontrole kachestva lekarstvennyih sredstv [Analytical chemistry in the creation, standardization and quality control of medicines]. Kharkiv: NMT, 1440.
Yarnyih, T. G., Melnik, G. N., Ruhmakova, O. A. (2013). Izuchenie vliyaniya temperaturyi na nekotoryie tehnologicheskie parametryi detskih suppozitoriev [The study of the effect of temperature on certain technological parameters of children's suppositories]. Retsept [Recipe], 3 (89), 93–97.
Yarnykh, T. H., Melnyk, H. M. (2012). Rozrobka tekhnolohii kombinovanykh supozytoriiv dlia vykorystannia u pediatrii [Development of technology of combined suppositories for use in pediatrics]. Visnyk farmatsii [Pharmacy Review], 4 (72), 12–14.
Yarnykh, T. H., Melnyk, H. M., Rukhmakova, O. A., Chushenko, V. M. (2013). Vyznachennia pokaznykiv yakosti ta vyvchennia stabilnosti rektalnykh supozytoriiv z ekstraktom solodkovoho korenia dlia ditei [Determination of quality indices and study of the stability of rectal suppositories with licorice extract for children]. Liky Ukrainy Plius [Medicines of Ukraine Plus], 2 (15), 16–18.
Yarnykh, T. H., Melnyk, H. M., Rukhmakova, O. A., Chushenko, V. M. (2013). Rozrobka metodyk identyfikatsii diiuchykh rechovyn u dytiachykh supozytoriiakh na osnovi pryrodnykh spoluk [Development of methods for the identification of active substances in children's suppositories on the basis of natural compounds]. Farmakom [Farmakom], 3, 44–48.
Amosov, А. S., Litvinenko, V. I. (2004). Solodka: tehnologiya preparatov (kratkiy obzor) [Licorice: technology of medicines (short review)]. Farmakom [Farmakom], 1, 53–61.
Egorov, M. V., Kurkin, V. A., Zapesochnaya, G. G. (2005). Validatsiya metodik kachestvennogo analiza syirya i preparatov solodki [Validation of methods for the qualitative analysis of raw materials and licorice medicines]. Farmatsiya [Pharmacy], 1, 9–12.
Copyright (c) 2018 Tatyana Yarnykh, Olga Rukhmakova
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.