@article{Yakimenko_2021, title={The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer}, url={https://journal.eu-jr.eu/ttism/article/view/2139}, DOI={10.21303/2585-6634.2021.002139}, abstractNote={<p>Colorectal cancer (CRC) ranks 2nd in the structure of mortality from malignant neoplasms (MN). One of the criteria for the prognosis of CRC may be a tumor stroma, which has not been widely used in clinical practice.</p> <p><strong>The aim</strong> was to determine the main morphological features of the stroma CRC T3N0-2M0 and search for prognostic criteria for their recurrence and lethal outcome according to the operating material and autopsy.</p> <p><strong>Materials and methods.</strong> Group I included primary CRC without recurrence. The average recurrence-free period was 5 years (62.5±16.5 months). Group II – primary CRC with recurrence; IIA – with recurrences within 5 years from the date of tumor removal that did not lead to death; IIB – with the appearance of recurrence and lethal consequence of the generalization of the tumor process within 5 years from the moment of removal of the primary tumor. CRC micropreparations made according to the standard method with G + E staining were studied; immunohistochemical study was performed using monoclonal antibodies to smooth muscle actin alpha.</p> <p><strong>Results</strong>. Stromal-parenchymal ratio &gt;50 % is a prognostic criterion for recurrence (p&lt;0.05) and shorter recurrence-free survival (p&lt;0.001) of patients with stage IIA-IIIB CRC. Immature stroma type CRC stage IIA-IIIB is associated with the presence of tumor budding (p&lt;0.001), G3 differentiation (p&lt;0.01), shorter recurrence-free survival (p&lt;0.001); among recurrent CRCs, the immature type of stroma is associated with the lethal outcome of patients (p&lt;0.05). Expressed levels of tumor-activated fibroblasts are one of the criteria for immature CRC stroma (p&lt;0.003), but as an independent prognostic criterion has limited prognostic value.</p> <p><strong>Conclusions</strong>. TSR and immature type of stroma are prognostic criteria for recurrence and recurrence period of CRC pT3N0-2M0, more typical of tumors of patients with recurrence and lethal outcome with the same ratio of tumors by differentiation.</p&gt;}, journal={Technology transfer: innovative solutions in medicine}, author={Yakimenko, Alina}, year={2021}, month={Oct.}, pages={13-15} }